PC11X_HUMAN » Protocadherin-11 X-linked

PC11X_HUMAN » Protocadherin-11 X-linked
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PC11X_HUMAN » Protocadherin-11 X-linked » Protocadherin-11; Protocadherin on the X chromosome;PCDH-X; Protocadherin-S;
Hydrophobic Thickness 34.0 ± 2.2 Å
Tilt Angle 2 ± 1°
ΔGtransfer -50.9 kcal/mol
ΔGfold -22.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 810-834 (808-839)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 25-115, PDBID: 1WUZ, Subunit A, Seq Identity:28%, Cadherin-like

AA: 144-240, PDBID: 4ZPS, Subunit A, Seq Identity:43%, Cadherin domain

AA: 254-346, PDBID: 2EE0, Subunit A, Seq Identity:67%, Cadherin domain

AA: 366-457, PDBID: 2WCP, Subunit A, Seq Identity:29%, Cadherin domain

AA: 471-561, PDBID: 2EE0, Subunit A, Seq Identity:39%, Cadherin domain

AA: 575-664, PDBID: 3PPE, Subunit A, Seq Identity:37%, Cadherin domain

AA: 682-773, PDBID: 2EE0, Subunit A, Seq Identity:33%, Cadherin domain

AA: 775-998, Protocadherin

UniProt annotation for PC11X_HUMAN » Protocadherin-11 X-linked
FUNCTION: Potential calcium-dependent cell-adhesion protein.

TISSUE SPECIFICITY: Expressed strongly in fetal brain and brain (cortex, amygdala, thalamus, substantia nigra, hippocampus, caudate nucleus and corpus callosum). Expressed at low level in testis.

UniProt features for PC11X_HUMAN » Protocadherin-11 X-linked
SIGNAL 1 23 Potential.
CHAIN 24 1347 Protocadherin-11 X-linked.
DOMAIN 26 139 Cadherin 1.
DOMAIN 140 249 Cadherin 2.
DOMAIN 250 355 Cadherin 3.
DOMAIN 362 466 Cadherin 4.
DOMAIN 467 570 Cadherin 5.
DOMAIN 571 673 Cadherin 6.
DOMAIN 677 795 Cadherin 7.
Amino Acid Sequence for PC11X_HUMAN » Protocadherin-11 X-linked
MDLLSGTYIF AVLLACVVFH SGAQEKNYTI REEMPENVLI GDLLKDLNLS LIPNKSLTTA MQFKLVYKTG DVPLIRIEED TGEIFTTGAR IDREKLCAGI PRDEHCFYEV EVAILPDEIF RLVKIRFLIE DINDNAPLFP ATVINISIPE NSAINSKYTL PAAVDPDVGI NGVQNYELIK SQNIFGLDVI ETPEGDKMPQ LIVQKELDRE EKDTYVMKVK VEDGGFPQRS STAILQVSVT DTNDNHPVFK ETEIEVSIPE NAPVGTSVTQ LHATDADIGE NAKIHFSFSN LVSNIARRLF HLNATTGLIT IKEPLDREET PNHKLLVLAS DGGLMPARAM VLVNVTDVND NVPSIDIRYI VNPVNDTVVL SENIPLNTKI ALITVTDKDA DHNGRVTCFT DHEIPFRLRP VFSNQFLLET AAYLDYESTK EYAIKLLAAD AGKPPLNQSA MLFIKVKDEN DNAPVFTQSF VTVSIPENNS PGIQLTKVSA MDADSGPNAK INYLLGPDAP PEFSLDCRTG MLTVVKKLDR EKEDKYLFTI LAKDNGVPPL TSNVTVFVSI IDQNDNSPVF THNEYNFYVP ENLPRHGTVG LITVTDPDYG DNSAVTLSIL DENDDFTIDS QTGVIRPNIS FDREKQESYT FYVKAEDGGR VSRSSSAKVT INVVDVNDNK PVFIVPPSNC SYELVLPSTN PGTVVFQVIA VDNDTGMNAE VRYSIVGGNT RDLFAIDQET GNITLMEKCD VTDLGLHRVL VKANDLGQPD SLFSVVIVNL FVNESVTNAT LINELVRKST EAPVTPNTEI ADVSSPTSDY VKILVAAVAG TITVVVVIFI TAVVRCRQAP HLKAAQKNKQ NSEWATPNPE NRQMIMMKKK KKKKKHSPKN LLLNFVTIEE TKADDVDSDG NRVTLDLPID LEEQTMGKYN WVTTPTTFKP DSPDLARHYK SASPQPAFQI QPETPLNSKH HIIQELPLDN TFVACDSISK CSSSSSDPYS VSDCGYPVTT FEVPVSVHTR PPMKEVVRSC TPMKESTTME IWIHPQPQRK SEGKVAGKSQ RRVTFHLPEG SQESSSDGGL GDHDAGSLTS TSHGLPLGYP QEEYFDRATP SNRTEGDGNS DPESTFIPGL KKAAEITVQP TVEEASDNCT QECLIYGHSD ACWMPASLDH SSSSQAQASA LCHSPPLSQA STQHHSPRVT QTIALCHSPP VTQTIALCHS PPPIQVSALH HSPPLVQATA LHHSPPSAQA SALCYSPPLA QAAAISHSSP LPQVIALHRS QAQSSVSLQQ GWVQGADGLC SVDQGVQGSA TSQFYTMSER LHPSDDSIKV IPLTTFTPRQ QARPSRGDSP IMEEHPL