P2C70_ARATH » Protein phosphatase 2C 70

P2C70_ARATH » Protein phosphatase 2C 70
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
P2C70_ARATH » Protein phosphatase 2C 70 » AtPP2C70; Kinase-associated protein phosphatase;
Hydrophobic Thickness 34.0 ± 3.2 Å
Tilt Angle 3 ± 2°
ΔGtransfer -49.2 kcal/mol
ΔGfold -24.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 2-29 (2-29)
Pathways none
PDB 1mzk (180-313)
OPM none
Complexes none
Interactions

BAK1, Complex: P2C70:BAK1, PubMed

BRI1, Complex: P2C70:BRI1, PubMed

CLV1, Complex: CLV1:P2C70, PubMed

CRK10, Complex: CRK10:P2C70

CRK6, Complex: CRK6:P2C70, PubMed

CRN, Complex: CRN:P2C70

FLS2, Complex: P2C70:FLS2, PubMed

SERK1, Complex: SERK1:P2C70, PubMed

TMK1, Complex: TMK1:P2C70

WAK1, Complex: WAK1:P2C70

Domains

AA: 208-284, PDBID: 1MZK, Subunit A, Seq Identity:100%, FHA domain

AA: 309-570, PDBID: 4YZG, Subunit B, Seq Identity:23%, Protein phosphatase 2C

UniProt annotation for P2C70_ARATH » Protein phosphatase 2C 70
FUNCTION: Dephosphorylates the Ser/Thr receptor-like kinase RLK5. May function as a signaling component in a pathway involving RLK5 (PubMed). Binds and dephosphorylates CLAVATA1 (CLV1). Functions as a negative regulator of the CLV1 signaling in plant development (PubMed, PubMed). Dephosphorylates SERK1 receptor kinase on threonine residues in the A-loop. Dephosphorylation of SERK1 controls SERK1 internalization (PubMed). Component of a signaling pathway which mediates adaptation to NaCl stress. Is not a component of the SALT OVERLY SENSITIVE (SOS) pathway (PubMed).

CATALYTIC ACTIVITY: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.

SUBUNIT: Association of RLK5 with kapp domain is dependent on phosphorylation of RLK5 and can be abolished by dephosphorylation. Interacts with SERK1 and CDC48A. Component of the SERK1 signaling complex, composed of KAPP, CDC48A, GRF6 or GRF7, SERK1, SERK2, SERK3/BAK1 and BRI1 (PubMed). Interacts with CLV1 (PubMed).

TISSUE SPECIFICITY: Expressed in all tissues examined.

UniProt features for P2C70_ARATH » Protein phosphatase 2C 70
CHAIN 1 581 Protein phosphatase 2C 70.
DOMAIN 208 259 FHA.
DOMAIN 289 581 PP2C-like.
Amino Acid Sequence for P2C70_ARATH » Protein phosphatase 2C 70
MAMIGMNIIG LFMVLMLLLI SLIILFACKP WRYFSRFRSS SRFSSTFKVG DLQRPLISDD GNLIQGQTSE VTREYDLEGA CYQNDGLLHS SLTEGRFYKQ RLPSSSPHFS QGESFVLEVI SEPSDNALVG QTLKLPAEKG SLAEVQTYDW QNNRNENLQY NLEKDRLINL SPRLVEDQRS WLFLEVIAGP AIGLQHAVNS TSSSKLPVKL GRVSPSDLAL KDSEVSGKHA QITWNSTKFK WELVDMGSLN GTLVNSHSIS HPDLGSRKWG NPVELASDDI ITLGTTTKVY VRISSQNEFQ IPFKIGVASD PMAMRRGGRK LPMEDVCHYK WPLPGANKFG LFCVCDGHGG SGAAQSAIKI IPEVLANILS DSLRKEKVLS KRDASDVLRD MFAKTEARLE EHQYEGCTAT VLLVWKDNEE NFFAQCANLG DSACVIHLGG RYIQMTEDHR VVSLSERKRF QEAGLALRDG ETRLFGINLA RMLGDKFPKQ QDSRFSAEPY ISEPLRIDQS SKDVFAVLAS DGLWDVVSPK KAVQLVLQMR DKERGRESSA EKIANGLLNE ARAMRTKDNT SIIYLDFDTS L