P24DB_ARATH » Transmembrane emp24 domain-containing protein p24delta11

P24DB_ARATH » Transmembrane emp24 domain-containing protein p24delta11
Magnify P24DB_ARATH » Transmembrane emp24 domain-containing protein p24delta11Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
P24DB_ARATH » Transmembrane emp24 domain-containing protein p24delta11 » p24 family protein delta11;p24delta11; p24 family protein delta2e;p24delta2e;
Hydrophobic Thickness 32.6 ± 2.8 Å
Tilt Angle 0 ± 0°
ΔGtransfer -17.0 kcal/mol
ΔGfold -13.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 193-213 (189-222)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 35-220, PDBID: 1M23, Subunit A, Seq Identity:22%, emp24/gp25L/p24 family/GOLD

UniProt annotation for P24DB_ARATH » Transmembrane emp24 domain-containing protein p24delta11
FUNCTION: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side (By similarity).

SUBUNIT: Probably oligomerizes with other members of the EMP24/GP25L family. Associates with the COPI vesicle coat (coatomer). Associates with the COPII vesicle coat (coatomer).

DOMAIN: The cytoplasmic C-terminal domain contains a functional dilysine-retrieval motif, which is involved in the retrograde Golgi-to-ER transport of the protein.

UniProt features for P24DB_ARATH » Transmembrane emp24 domain-containing protein p24delta11
SIGNAL 1 35 Potential.
CHAIN 36 225 Transmembrane emp24 domain-containing protein p24delta11.
DOMAIN 45 160 GOLD.
COILED 175 188 Potential.
MOTIF 218 225 COPI vesicle coat-binding (By similarity).
MOTIF 218 219 COPII vesicle coat-binding (By similarity).
Amino Acid Sequence for P24DB_ARATH » Transmembrane emp24 domain-containing protein p24delta11
MDLLPSRYKI HKTKLRWILT MMTMMMMMVM RRGESMRLDM ESGNTKCISD DIKTNYMTVG TYSIVNPNEG HHLPPSHKLF VTVSSPKGKS HHHAENVESG KFVFTAEETG DYMTCFVAPG YRPTAKFAVD FEWKSGVEAK DWTTIAKRGQ ITMLEVEVRK LLDVTETIHE EMFQLIERER EMQELNRSTN SRMAALSLLS FVVTMSVAGL QLRHLKSFLE RKKLL