P24DA_ARATH » Transmembrane emp24 domain-containing protein p24delta10

P24DA_ARATH » Transmembrane emp24 domain-containing protein p24delta10
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
P24DA_ARATH » Transmembrane emp24 domain-containing protein p24delta10 » p24 family protein delta10;p24delta10; p24 family protein delta2d;p24delta2d;
Hydrophobic Thickness 35.6 ± 1.8 Å
Tilt Angle 1 ± 0°
ΔGtransfer -46.8 kcal/mol
ΔGfold -15.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 181-206 (176-211)
Pathways none
PDB none
OPM none
Complexes none
Interactions

BETL2, Complex: P24DA:BETL2

C71B4, Complex: P24DA:C71B4

CRK40, Complex: P24DA:CRK40

ERL1, Complex: P24DA:ERL1

PAM74, Complex: P24DA:PAM74

UBC34, Complex: P24DA:UBC34

WAK3, Complex: P24DA:WAK3

Domains

AA: 24-209, PDBID: 1M23, Subunit A, Seq Identity:21%, emp24/gp25L/p24 family/GOLD

UniProt annotation for P24DA_ARATH » Transmembrane emp24 domain-containing protein p24delta10
FUNCTION: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side (By similarity).

SUBUNIT: Probably oligomerizes with other members of the EMP24/GP25L family. Associates with the COPI vesicle coat (coatomer). Associates with the COPII vesicle coat (coatomer).

DOMAIN: The cytoplasmic C-terminal domain contains a functional dilysine-retrieval motif, which is involved in the retrograde Golgi-to-ER transport of the protein.

MISCELLANEOUS: The lumenal coiled-coil domain is required for the Golgi subcellular location.

UniProt features for P24DA_ARATH » Transmembrane emp24 domain-containing protein p24delta10
SIGNAL 1 24 Potential.
CHAIN 25 214 Transmembrane emp24 domain-containing protein p24delta10.
DOMAIN 34 149 GOLD.
COILED 164 177 Potential.
MOTIF 207 214 COPI vesicle coat-binding (By similarity).
MOTIF 207 208 COPII vesicle coat-binding (By similarity).
Amino Acid Sequence for P24DA_ARATH » Transmembrane emp24 domain-containing protein p24delta10
MFLQSQKLWT MLLILAIWSP ISHSLHFDLH SGRTKCIAED IKSNSMTVGK YNIDNPHEGQ ALPQTHKISV KVTSNSGNNY HHAEQVDSGQ FAFSAVEAGD YMACFTAVDH KPEVSLSIDF EWKTGVQSKS WANVAKKSQV EVMEFEVKSL LDTVNSIHEE MYYLRDREEE MQDLNRSTNT KMAWLSVLSF FVCIGVAGMQ FLHLKTFFEK KKVI