P24D9_ARATH » Transmembrane emp24 domain-containing protein p24delta9

P24D9_ARATH » Transmembrane emp24 domain-containing protein p24delta9
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
P24D9_ARATH » Transmembrane emp24 domain-containing protein p24delta9 » p24 family protein delta2c;p24delta2c; p24 family protein delta9;p24delta9;
Hydrophobic Thickness 40.4 ± 1.4 Å
Tilt Angle 0 ± 0°
ΔGtransfer -46.3 kcal/mol
ΔGfold -15.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 180-206 (176-211)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 24-209, PDBID: 1M23, Subunit A, Seq Identity:21%, emp24/gp25L/p24 family/GOLD

UniProt annotation for P24D9_ARATH » Transmembrane emp24 domain-containing protein p24delta9
FUNCTION: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side (By similarity).

SUBUNIT: Probably oligomerizes with other members of the EMP24/GP25L family. Associates with the COPI vesicle coat (coatomer). Associates with the COPII vesicle coat (coatomer).

DOMAIN: The cytoplasmic C-terminal domain contains a functional dilysine-retrieval motif, which is involved in the retrograde Golgi-to-ER transport of the protein.

UniProt features for P24D9_ARATH » Transmembrane emp24 domain-containing protein p24delta9
SIGNAL 1 24 Potential.
CHAIN 25 214 Transmembrane emp24 domain-containing protein p24delta9.
DOMAIN 34 149 GOLD.
COILED 164 177 Potential.
MOTIF 207 214 COPI vesicle coat-binding (By similarity).
MOTIF 207 208 COPII vesicle coat-binding (By similarity).
Amino Acid Sequence for P24D9_ARATH » Transmembrane emp24 domain-containing protein p24delta9
MFLRSLNLCT ILLFLAISSQ VSQSLHFELQ SGRTKCISED IKSNSMTVGK YTVVNPNEAH PSPQSHKISI RVTSSYGNTY HHAEDVESGQ FAFTAVESGD YMACYTAVDH KPEVTLSIDF DWRTGVQSKS WSSVAKKSQV EVMEFDVKRL IETVNSIHEE MFYLREREEE MQNLNRATNS KMAWLSFLSL FVCLGVAGMQ FVHLKTFFEK KKVI