P24D8_ARATH » Transmembrane emp24 domain-containing protein p24delta8

P24D8_ARATH » Transmembrane emp24 domain-containing protein p24delta8
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
P24D8_ARATH » Transmembrane emp24 domain-containing protein p24delta8 » p24 family protein delta2b;p24delta2b; p24 family protein delta8;p24delta8;
Hydrophobic Thickness 30.8 ± 1.4 Å
Tilt Angle 41 ± 0°
ΔGtransfer -16.9 kcal/mol
ΔGfold -13.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 179-205 (175-210)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 22-208, PDBID: 1M23, Subunit A, Seq Identity:21%, emp24/gp25L/p24 family/GOLD

UniProt annotation for P24D8_ARATH » Transmembrane emp24 domain-containing protein p24delta8
FUNCTION: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side (By similarity). On Golgi membranes, acts as primary receptor for ARF1-GDP which is involved in COPI-vesicle formation.

SUBUNIT: Probably oligomerizes with other members of the EMP24/GP25L family (By similarity). Associates with the COPI vesicle coat (coatomer). Associates with the COPII vesicle coat (coatomer). Interacts with ARF1 (GDP-bound).

DOMAIN: The cytoplasmic C-terminal domain contains a functional dilysine-retrieval motif, which is involved in the retrograde Golgi-to-ER transport of the protein.

UniProt features for P24D8_ARATH » Transmembrane emp24 domain-containing protein p24delta8
SIGNAL 1 22 Potential.
CHAIN 23 213 Transmembrane emp24 domain-containing protein p24delta8.
DOMAIN 32 148 GOLD.
REGION 202 213 Interaction with ARF1 (By similarity).
COILED 163 176 Potential.
MOTIF 206 213 COPI vesicle coat-binding.
MOTIF 206 207 COPII vesicle coat-binding.
Amino Acid Sequence for P24D8_ARATH » Transmembrane emp24 domain-containing protein p24delta8
MDLCRSSILL LIIALLSPRT LSMRYELKSS KTKCIGEEIH ENAMSIGKYF IVNPNEDNHP LPDSHKIIVK VMPPQGKNLH EADKVEAGQF SFTAYENGSY VACITAIDYK PETTLTIDFD WKTGVHSKEW TNVAKKSQVD MMEYQVKTLM DTVISIHEEM YYLREREEEM QELNRSTNSK MAWLSFGSLV VCLSVAGLQF WHLKTFFEKK KLI