P24D7_ARATH » Transmembrane emp24 domain-containing protein p24delta7

P24D7_ARATH » Transmembrane emp24 domain-containing protein p24delta7
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
P24D7_ARATH » Transmembrane emp24 domain-containing protein p24delta7 » p24 family protein delta2a;p24delta2a; p24 family protein delta7;p24delta7;
Hydrophobic Thickness 32.0 ± 2.0 Å
Tilt Angle 0 ± 0°
ΔGtransfer -33.6 kcal/mol
ΔGfold -14.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 179-204 (174-209)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 22-207, PDBID: 1M23, Subunit A, Seq Identity:19%, emp24/gp25L/p24 family/GOLD

UniProt annotation for P24D7_ARATH » Transmembrane emp24 domain-containing protein p24delta7
FUNCTION: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side (By similarity).

SUBUNIT: Probably oligomerizes with other members of the EMP24/GP25L family. Associates with the COPI vesicle coat (coatomer). Associates with the COPII vesicle coat (coatomer).

DOMAIN: The cytoplasmic C-terminal domain contains a functional dilysine-retrieval motif, which is involved in the retrograde Golgi-to-ER transport of the protein.

UniProt features for P24D7_ARATH » Transmembrane emp24 domain-containing protein p24delta7
SIGNAL 1 22 Potential.
CHAIN 23 212 Transmembrane emp24 domain-containing protein p24delta7.
DOMAIN 32 147 GOLD.
COILED 162 175 Potential.
MOTIF 205 212 COPI vesicle coat-binding (By similarity).
MOTIF 205 206 COPII vesicle coat-binding (By similarity).
Amino Acid Sequence for P24D7_ARATH » Transmembrane emp24 domain-containing protein p24delta7
MNHRRSSIVL LILSILSPVT LSIRYELLSG HTKCISEEIH ANAMTIGKYS IINPHEDHPL PSSHKVTVRV TSPQGTAYHE SDGVESGQFS FVAVETGDYI SCFSAVDHKP ETTLIIDFDW RTGIHTKDWS NVAKKSQVET MEFEVKKLFE TVNGIHDEMF YLRDREEEMH NLNIATNSKM AWLSFVSLAV CLSVAGLQFW HLKTFFQKKK LI