P24D6_ARATH » Transmembrane emp24 domain-containing protein p24delta6

P24D6_ARATH » Transmembrane emp24 domain-containing protein p24delta6
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
P24D6_ARATH » Transmembrane emp24 domain-containing protein p24delta6 » p24 family protein delta1d;p24delta1d; p24 family protein delta6;p24delta6;
Hydrophobic Thickness 27.6 ± 2.7 Å
Tilt Angle 34 ± 0°
ΔGtransfer -16.2 kcal/mol
ΔGfold -11.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 187-208 (187-214)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 26-212, PDBID: 1M23, Subunit A, Seq Identity:24%, emp24/gp25L/p24 family/GOLD

UniProt annotation for P24D6_ARATH » Transmembrane emp24 domain-containing protein p24delta6
FUNCTION: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side (By similarity).

SUBUNIT: Probably oligomerizes with other members of the EMP24/GP25L family. Associates with the COPI vesicle coat (coatomer). Associates with the COPII vesicle coat (coatomer).

DOMAIN: The cytoplasmic C-terminal domain contains a functional dilysine-retrieval motif, which is involved in the retrograde Golgi-to-ER transport of the protein.

UniProt features for P24D6_ARATH » Transmembrane emp24 domain-containing protein p24delta6
SIGNAL 1 26 Potential.
CHAIN 27 217 Transmembrane emp24 domain-containing protein p24delta6.
DOMAIN 36 152 GOLD.
COILED 138 160 Potential.
MOTIF 210 217 COPI vesicle coat-binding (By similarity).
MOTIF 210 211 COPII vesicle coat-binding (By similarity).
Amino Acid Sequence for P24D6_ARATH » Transmembrane emp24 domain-containing protein p24delta6
MAISPVLFIG LIYLAGGGSL FPGVEAIWLT VPESGERCVY EEIQANVVVV LDYICIDDAF TQLGPTLDVR VTSPYGKELY KIANVTHGQA AFTTSESGTF LACLAMHHDQ SHHSVNSSVI VSLDWKMGIR AKDWDSVAKK EKIEGVELEI RRSTEYASAI RANILYLRIR EAYMREINEK TNTRVNQLGL MSLGVAIVVS ISQVLYLKRY FLKKKLI