P24D5_ARATH » Transmembrane emp24 domain-containing protein p24delta5

P24D5_ARATH » Transmembrane emp24 domain-containing protein p24delta5
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
P24D5_ARATH » Transmembrane emp24 domain-containing protein p24delta5 » Atp24;p24 family protein delta1c;p24delta1c; p24 family protein delta5;p24delta5;
Hydrophobic Thickness 33.6 ± 2.4 Å
Tilt Angle 0 ± 2°
ΔGtransfer -38.0 kcal/mol
ΔGfold -11.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 183-208 (178-213)
Pathways none
PDB none
OPM none
Complexes none
Interactions

P24B2, Complex: P24D5:P24B2

Domains

AA: 29-211, PDBID: 1M23, Subunit A, Seq Identity:23%, emp24/gp25L/p24 family/GOLD

UniProt annotation for P24D5_ARATH » Transmembrane emp24 domain-containing protein p24delta5
FUNCTION: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side (By similarity). Interacts with p24beta2 at endoplasmic reticulum export sites for endoplasmic reticulum exit and coupled transport to the Golgi apparatus. Once in the Golgi, interacts very efficiently with the COPI machinery for retrograde transport back to the endoplasmic reticulum.

SUBUNIT: Probably oligomerizes with other members of the EMP24/GP25L family (By similarity). Associates with the COPI vesicle coat (coatomer) (By similarity). Associates with the COPII vesicle coat (coatomer) (By similarity). Interacts with p24beta2.

DOMAIN: The cytoplasmic C-terminal domain contains a functional dilysine-retrieval motif, which is involved in the retrograde Golgi-to-ER transport of the protein.

UniProt features for P24D5_ARATH » Transmembrane emp24 domain-containing protein p24delta5
SIGNAL 1 27 Potential.
CHAIN 28 216 Transmembrane emp24 domain-containing protein p24delta5.
DOMAIN 38 151 GOLD.
COILED 137 159 Potential.
MOTIF 209 216 COPI vesicle coat-binding (By similarity).
MOTIF 209 210 COPII vesicle coat-binding (By similarity).
Amino Acid Sequence for P24D5_ARATH » Transmembrane emp24 domain-containing protein p24delta5
MAINRIAHGS LFLTVVLFFL TVNYGEAIWL TIPTTGGTKC VSEEIQSNVV VLADYYVVDE HNPENTPAVS SKVTSPYGNN LHHQENVTHG QFAFTTQEAG NYLACFWIDS SHHLANPITL GVDWKMGIAA KDWDSVAKKE KIEGVELQLR RLEGLVLSIR ENLNYIKDRE AEMREVSETT NSRVAWFSIM SLGVCVVVVG SQILYLKRYF HKKKLI