P24D4_ARATH » Transmembrane emp24 domain-containing protein p24delta4

P24D4_ARATH » Transmembrane emp24 domain-containing protein p24delta4
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
P24D4_ARATH » Transmembrane emp24 domain-containing protein p24delta4 » p24 family protein delta1b;p24delta1b; p24 family protein delta4;p24delta4;
Hydrophobic Thickness 34.0 ± 2.2 Å
Tilt Angle 7 ± 0°
ΔGtransfer -37.6 kcal/mol
ΔGfold -12.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 182-202 (178-209)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 25-207, PDBID: 1M23, Subunit A, Seq Identity:25%, emp24/gp25L/p24 family/GOLD

UniProt annotation for P24D4_ARATH » Transmembrane emp24 domain-containing protein p24delta4
FUNCTION: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Required for trafficking GLL23, a component of the PYK10 complex. May act as a receptor facilitating its packing into COPII carriers and export from the endoplasmic reticulum.

SUBUNIT: Probably oligomerizes with other members of the EMP24/GP25L family (By similarity). Associates with the COPI vesicle coat (coatomer). Associates with the COPII vesicle coat (coatomer).

DOMAIN: The cytoplasmic C-terminal domain contains a functional dilysine-retrieval motif, which is involved in the retrograde Golgi-to-ER transport of the protein.

UniProt features for P24D4_ARATH » Transmembrane emp24 domain-containing protein p24delta4
SIGNAL 1 25 Potential.
CHAIN 26 212 Transmembrane emp24 domain-containing protein p24delta4.
DOMAIN 35 147 GOLD.
COILED 133 155 Potential.
MOTIF 205 212 COPI vesicle coat-binding.
MOTIF 205 206 COPII vesicle coat-binding.
Amino Acid Sequence for P24D4_ARATH » Transmembrane emp24 domain-containing protein p24delta4
MKKKMIPTTI LLSALIFSLS PICEAVWLTV PHTGSKCVSE EIQSNVIVLA DYLVISEEHS IFPTVSVKVT APYGTVLHHR ENTTNGQFAF TTQESGTYLA CFEADAKSHG NKDFSINIDW KTGIAAKDWD SIARKEKIEG VELEFKKLEG AVEAIHENLI YLRNREAEMR IVSEKTNSRV AWYSIMSLGI CIVVSGLQIL YLKQYFEKKK LI