P24B3_ARATH » Transmembrane emp24 domain-containing protein p24beta3

P24B3_ARATH » Transmembrane emp24 domain-containing protein p24beta3
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Topology in Golgi apparatus membrane
TopologyGolgi lumenal side
cytoplasmic side
P24B3_ARATH » Transmembrane emp24 domain-containing protein p24beta3 » p24 family protein beta2;p24beta2; p24 family protein beta3;p24beta3;
Hydrophobic Thickness 31.6 ± 4.0 Å
Tilt Angle 23 ± 15°
ΔGtransfer -15.2 kcal/mol
ΔGfold -7.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 177-200 (173-203)
Pathways none
PDB none
OPM none
Complexes none
Interactions

BETL2, Complex: P24B3:BETL2

MSBP1, Complex: P24B3:MSBP1

PAM74, Complex: P24B3:PAM74

SSRA, Complex: P24B3:SSRA

UBC34, Complex: P24B3:UBC34

WAK3, Complex: P24B3:WAK3

Domains

AA: 26-206, PDBID: 1M23, Subunit A, Seq Identity:21%, emp24/gp25L/p24 family/GOLD

UniProt annotation for P24B3_ARATH » Transmembrane emp24 domain-containing protein p24beta3
FUNCTION: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side (By similarity).

SUBUNIT: Probably oligomerizes with other members of the EMP24/GP25L family. Associates with the COPI vesicle coat (coatomer). Associates with the COPII vesicle coat (coatomer).

DOMAIN: The cytoplasmic C-terminal domain contains an Arg-Val motif, which is involved in the anterograde ER-to-Golgi transport of the protein.

UniProt features for P24B3_ARATH » Transmembrane emp24 domain-containing protein p24beta3
SIGNAL 1 27 Potential.
CHAIN 28 214 Transmembrane emp24 domain-containing protein p24beta3.
DOMAIN 35 122 GOLD.
COILED 140 158 Potential.
MOTIF 204 214 COPI vesicle coat-binding (Potential).
MOTIF 204 205 COPII vesicle coat-binding (Potential).
MOTIF 213 214 Required for the export from the endoplasmic reticulum to the Golgi (By similarity).
Amino Acid Sequence for P24B3_ARATH » Transmembrane emp24 domain-containing protein p24beta3
MERRQAKIHV FVLIGLILLN SINQISSLSV TVNDEECVQE YVLYEGDTVS GNFVVVDHDI FWGSDHPGLD FTVTSPAGNI VQTLKGTSGD KFEFKAPKSG MYKFCFHNPY STPETVSFYI HVGHIPNEHD LAKDEHLDPV NVKIAELREA LESVVAEQKY LKARDTRHRH TNESTRKRVI FYTVGEYIFL AAASGLQVLY IRKLFSKSVA YNRV