P24B2_ARATH » Transmembrane emp24 domain-containing protein p24beta2

P24B2_ARATH » Transmembrane emp24 domain-containing protein p24beta2
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Topology in Golgi apparatus membrane
TopologyGolgi lumenal side
cytoplasmic side
P24B2_ARATH » Transmembrane emp24 domain-containing protein p24beta2 » p24 family protein beta1;p24beta1; p24 family protein beta2;p24beta2;
Hydrophobic Thickness 27.6 ± 3.6 Å
Tilt Angle 0 ± 3°
ΔGtransfer -33.8 kcal/mol
ΔGfold -9.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 173-195 (167-202)
Pathways none
PDB none
OPM none
Complexes none
Interactions

BETL2, Complex: P24B2:BETL2

P24D5, Complex: P24D5:P24B2

PAM74, Complex: P24B2:PAM74

WAK3, Complex: P24B2:WAK3

Domains

AA: 21-200, PDBID: 1M23, Subunit A, Seq Identity:11%, emp24/gp25L/p24 family/GOLD

UniProt annotation for P24B2_ARATH » Transmembrane emp24 domain-containing protein p24beta2
FUNCTION: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side (By similarity). Interacts with p24delta5 at endoplasmic reticulum export sites for endoplasmic reticulum exit and coupled transport to the Golgi apparatus.

SUBUNIT: Probably oligomerizes with other members of the EMP24/GP25L family (By similarity). Associates with the COPI vesicle coat (coatomer) (By similarity). Associates with the COPII vesicle coat (coatomer) (By similarity). Interacts with p24delta5.

DOMAIN: The cytoplasmic C-terminal domain contains an Arg-Val motif, which is involved in the anterograde ER-to-Golgi transport of the protein.

UniProt features for P24B2_ARATH » Transmembrane emp24 domain-containing protein p24beta2
SIGNAL 1 21 Potential.
CHAIN 22 208 Transmembrane emp24 domain-containing protein p24beta2.
DOMAIN 29 116 GOLD.
COILED 134 149 Potential.
MOTIF 198 208 COPI vesicle coat-binding (Potential).
MOTIF 198 199 COPII vesicle coat-binding (Potential).
MOTIF 207 208 Required for the export from the endoplasmic reticulum to the Golgi.
Amino Acid Sequence for P24B2_ARATH » Transmembrane emp24 domain-containing protein p24beta2
MSLKGTIVLL GLLWSFQATL GIRFVIDREE CFSHKAEYEG DTLHVSFVVI KSDSQWHFNE DGVDLVIHGP TGEQIHDFRE QISAKHDFVV QKKGVYRFCF TNKSPYHETI DFDVQLGHFA YYDQHAKDEH FTPLMEQISK LEEALYNIQF EQHWLEAQTD RQAIVNENMS KRAVHKALFE SFALIGASFL QVYLLRRLFE RKLGMSRV