P121C_HUMAN » Nuclear envelope pore membrane protein POM 121C

P121C_HUMAN » Nuclear envelope pore membrane protein POM 121C
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Topology in Nuclear membrane
Topologyouter side
inner side
P121C_HUMAN » Nuclear envelope pore membrane protein POM 121C » Nuclear pore membrane protein 121-2;POM121-2; Pore membrane protein of 121 kDa C;
Hydrophobic Thickness 31.6 ± 2.0 Å
Tilt Angle 50 ± 3°
ΔGtransfer -25.6 kcal/mol
ΔGfold -17.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 34-66 (34-71)
Pathways

RNA transport (KEGG)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 294-529, PDBID: 4YI0, Subunit A, Seq Identity:80%, POM121 family

UniProt annotation for P121C_HUMAN » Nuclear envelope pore membrane protein POM 121C
FUNCTION: Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL).

DOMAIN: Contains F-X-F-G repeats.

UniProt features for P121C_HUMAN » Nuclear envelope pore membrane protein POM 121C
CHAIN 1 1229 Nuclear envelope pore membrane protein POM 121C.
REGION 1 398 Required for targeting to the nucleus and nuclear pore complex.
REGION 1 40 Cisternal side (Potential).
REGION 62 1229 Pore side (Potential).
Amino Acid Sequence for P121C_HUMAN » Nuclear envelope pore membrane protein POM 121C
MSPAAAAAGA GERRRPIASV RDGRGRGCGG PAGAALLGLS LVGLLLYLVP AAAALAWLAV GTTAAWWGLS REPRGSRPLS SFVQKARHRR TLFASPPAKS TANGNLLEPR TLLEGPDPAE LLLMGSYLGK PGPPQPAPAP EGQDLRNRPG RRPPARPAPR STPPSPPTHR VHHFYPSLPT PLLRPSGRPS PRDRGTLPDR FVITPRRRYP IHQTQYSCPG VLPTVCWNGY HKKAVLSPRN SRMVCSPVTV RIAPPDRRFS RSAIPEQIIS STLSSPSSNA PDPCAKETVL SALKEKKKKR TVEEEDQIFL DGQENKRRRH DSSGSGHSAF EPLVASGVPA SFVPKPGSLK RGLNSQSSDD HLNKRSRSSS MSSLTGAYTS GIPSSSRNAI TSSYSSTRGI SQLWKRNGPS SSPFSSPASS RSQTPERPAK KIREEELCHH SSSSTPLAAD KESQGEKAAD TTPRKKQNSN SQSTPGSSGQ RKRKVQLLPS RRGEQLTLPP PPQLGYSITA EDLDLEKKAS LQWFNQALED KSDAASNSVT ETPPTTQPSF TFTLPAAATA SPPTSLLAPS TNPLLESLKK MQTPPSLPPC PESAGAATTE ALSPPKTPSL LPPLGLSQSG PPGLLPSPSF DSKPPTTLLG LIPAPSMVPA TDTKAPPTLQ AETATKPQAT SAPSPAPKQS FLFGTQNTSP SSPAAPAASS ASPMFKPIFT APPKSEKEGP TPPGPSVTAT APSSSSLPTT TSTTAPTFQP VFSSMGPPAS VPLPAPFFKQ TTTPATAPTT TAPLFTGLAS ATSAVAPITS ASPSTDSASK PAFGFGINSV SSSSVSTTTS TATAASQPFL FGAPQASAAS FTPAMGSIFQ FGKPPALPTT TTVTTFSQSL PTAVPTATSS SAADFSGFGS TLATSAPATS SQPTLTFSNT STPTFNIPFG SSAKSPLPSY PGANPQPAFG AAEGQPPGAA KPALTPSFGS SFTFGNSAAP APATAPTPAP ASTIKIVPAH VPTPIQPTFG GATHSAFGLK ATASAFGAPA SSQPAFGGST AVFSFGAATS SGFGATTQTA SSGSSSSVFG STTPSPFTFG GSAAPAGSGS FGINVATPGS SATTGAFSFG AGQSGSTATS TPFTGGLGQN ALGTTGQSTP FAFNVGSTTE SKPVFGGTAT PTFGQNTPAP GVGTSGSSLS FGASSAPAQG FVGVGPFGSA APSFSIGAGS KTPGARQRLQ ARRQHTRKK