OX2G_HUMAN » OX-2 membrane glycoprotein

OX2G_HUMAN » OX-2 membrane glycoprotein
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
OX2G_HUMAN » OX-2 membrane glycoprotein »
Hydrophobic Thickness 38.4 ± 1.2 Å
Tilt Angle 0 ± 0°
ΔGtransfer -55.2 kcal/mol
ΔGfold -26.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 231-260 (231-262)
Pathways

Immune System (Reactome)

PDB none
OPM none
Complexes

OX2G:MO2R1_MOUSE

Interactions

MO2R1, Complex: MO2R1:OX2G, PDBID: 4bfi, PubMed

Domains

AA: 36-136, PDBID: 4BFI, Subunit B, Seq Identity:64%, Immunoglobulin domain

AA: 143-229, PDBID: 4BFI, Subunit B, Seq Identity:74%, Immunoglobulin domain

UniProt annotation for OX2G_HUMAN » OX-2 membrane glycoprotein
FUNCTION: Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.

SUBUNIT: CD200 and CD200R1 interact via their respective N- terminal Ig-like domains.

UniProt features for OX2G_HUMAN » OX-2 membrane glycoprotein
SIGNAL 1 30 Potential.
CHAIN 31 278 OX-2 membrane glycoprotein.
DOMAIN 31 141 Ig-like V-type.
DOMAIN 142 232 Ig-like C2-type.
DISULFID 51 121 Potential.
DISULFID 160 214 Potential.
Amino Acid Sequence for OX2G_HUMAN » OX-2 membrane glycoprotein
MERLVIRMPF CHLSTYSLVW VMAAVVLCTA QVQVVTQDER EQLYTPASLK CSLQNAQEAL IVTWQKKKAV SPENMVTFSE NHGVVIQPAY KDKINITQLG LQNSTITFWN ITLEDEGCYM CLFNTFGFGK ISGTACLTVY VQPIVSLHYK FSEDHLNITC SATARPAPMV FWKVPRSGIE NSTVTLSHPN GTTSVTSILH IKDPKNQVGK EVICQVLHLG TVTDFKQTVN KGYWFSVPLL LSIVSLVILL VLISILLYWK RHRNQDRGEL SQGVQKMT