OLR1_HUMAN » Oxidized low-density lipoprotein receptor 1

OLR1_HUMAN » Oxidized low-density lipoprotein receptor 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
OLR1_HUMAN » Oxidized low-density lipoprotein receptor 1 » Ox-LDL receptor 1; C-type lectin domain family 8 member A;Lectin-like oxidized LDL receptor 1;LOX-1; Lectin-like oxLDL receptor 1; hLOX-1; Lectin-type oxidized LDL receptor 1;
Hydrophobic Thickness 36.8 ± 1.6 Å
Tilt Angle 0 ± 3°
ΔGtransfer -45.8 kcal/mol
ΔGfold -17.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology In
TM Segments 33-60 (33-62)
Pathways

Hemostasis (Reactome)

Phagosome (KEGG)

PPAR signaling pathway (KEGG)

PDB 3vlg (133-273), 1ypo (A/B...=142-272), 1ypq (A/B=136-270), 1ypu (A/B=136-270), 1yxk (A/B=136-270), 1yxj (A/B=143-271)
OPM none
Complexes

OLR1:OLR1_HUMAN

Interactions

MPRD, Complex: MPRD:OLR1

OLR1, Complex: Homodimer of oxidized low-density lipoprotein receptor 1, PDBID: 1YPQ

Domains

AA: 32-158, PDBID: 1YPO, Subunit B, Seq Identity:100%, Ly49-like protein, N-terminal region

AA: 161-266, PDBID: 1YPO, Subunit B, Seq Identity:100%, Lectin C-type domain

UniProt annotation for OLR1_HUMAN » Oxidized low-density lipoprotein receptor 1
FUNCTION: Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro- oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro- atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram- positive bacteria.

SUBUNIT: Homodimer; disulfide-linked. May form a hexamer composed of 3 homodimers. Interacts with HSP70.

TISSUE SPECIFICITY: Expressed at high level in endothelial cells and vascular-rich organs such as placenta, lung, liver and brain, aortic intima, bone marrow, spinal cord and substantia nigra. Also expressed at the surface of dendritic cells. Widely expressed at intermediate and low level.

INDUCTION: By inflammatory cytokines such as TNF, IFNG/IFN-gamma, IL6/interleukin-6 and by pathological conditions such as hyperlipidemia, hypertension and diabetes mellitus. Up-regulated in atherosclerotic lesions, by oxLDL, reactive oxygen species and fluid shear stress, suggesting that it may participate in amplification of oxLDL-induced vascular dysfunction.

DOMAIN: The cytoplasmic region is required for subcellular sorting on the cell surface.

DOMAIN: The C-type lectin domain mediates the recognition and binding of oxLDL.

DISEASE: Note=Independent association genetic studies have implicated OLR1 gene variants in myocardial infarction susceptibility.

DISEASE: Note=OLR1 may be involved in Alzheimer disease (AD). Involvement in AD is however unclear: according to some authors (PubMed, PubMed and PubMed), variations in OLR1 modify the risk of AD, while according to other (PubMed and PubMed) they do not.

UniProt features for OLR1_HUMAN » Oxidized low-density lipoprotein receptor 1
CHAIN 1 273 Oxidized low-density lipoprotein receptor 1.
CHAIN ? 273 Oxidized low-density lipoprotein receptor 1, soluble form.
DOMAIN 151 265 C-type lectin.
REGION 58 150 Neck.
COILED 64 123 Potential.
SITE 183 183 Not glycosylated (Probable).
DISULFID 140 140 Interchain.
DISULFID 144 155
DISULFID 172 264
DISULFID 243 256
Amino Acid Sequence for OLR1_HUMAN » Oxidized low-density lipoprotein receptor 1
MTFDDLKIQT VKDQPDEKSN GKKAKGLQFL YSPWWCLAAA TLGVLCLGLV VTIMVLGMQL SQVSDLLTQE QANLTHQKKK LEGQISARQQ AEEASQESEN ELKEMIETLA RKLNEKSKEQ MELHHQNLNL QETLKRVANC SAPCPQDWIW HGENCYLFSS GSFNWEKSQE KCLSLDAKLL KINSTADLDF IQQAISYSSF PFWMGLSRRN PSYPWLWEDG SPLMPHLFRV RGAVSQTYPS GTCAYIQRGA VYAENCILAA FSICQKKANL RAQ