NVJ1_YEAST » Nucleus-vacuole junction protein 1

NVJ1_YEAST » Nucleus-vacuole junction protein 1
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Topology in Nuclear outer membrane
Topologyintermembrane space
cytoplasmic side
NVJ1_YEAST » Nucleus-vacuole junction protein 1 »
Hydrophobic Thickness 31.2 ± 3.4 Å
Tilt Angle 1 ± 9°
ΔGtransfer -22.0 kcal/mol
ΔGfold -15.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 92-113 (89-116)
Pathways none
PDB none
OPM none
Complexes none
Interactions

CY1, Complex: CY1:NVJ1, PubMed

Domains none
UniProt annotation for NVJ1_YEAST » Nucleus-vacuole junction protein 1
FUNCTION: Involved in the formation of nucleus-vacuole (NV) junctions during piecemeal microautophagy of the nucleus (PMN). NV junctions are interorganelle interfaces mediated by NVJ1 in the nuclear envelope and VAC8 on the vacuole membrane. Together, NVJ1 and VAC8 form Velcro-like patches through which teardrop-like portions of the nucleus are pinched off into the vacuolar lumen and degraded by the PMN process. Acts also as an outer-nuclear membrane receptor for OSH1 and TSC13.

SUBUNIT: Interacts with OSH1, TSC13 and VAC8.

MISCELLANEOUS: Present with 1900 molecules/cell in log phase SD medium.

UniProt features for NVJ1_YEAST » Nucleus-vacuole junction protein 1
SIGNAL 1 22 Potential.
CHAIN 23 321 Nucleus-vacuole junction protein 1.
REGION 73 125 TSC13-binding.
REGION 139 195 OSH1-binding.
REGION 233 321 VAC8-binding.
Amino Acid Sequence for NVJ1_YEAST » Nucleus-vacuole junction protein 1
MTRPPLVRGI FSLGLSVAVL KGVEKTVRKH LERQGWIEPQ KVDYELIFTI DRLKNLVDNK REALTAEQPD AGELSWRKVF NFISRQSSEL DTRIYVLILL LSFLLPIAWT VLDGDRETTL EDKDNDCNVD LIENERRLKH YNDGERAVLQ FGKNRSEPII LSYKDMNVLE GEHEFTSKEE HSNSHLTSKS ENALNQVGSE DLLGCHLEKQ LEEDKNEPNG EADGEDDNNR EKDCSSSSEV ESQSKCRKES TAEPDSLSRD TRTTSSLKSS TSFPISFKGS IDLKSLNQPS SLLHIQVSPT KSSNLDAQVN TEQAYSQPFR Y