NRX3A_HUMAN » Neurexin-3

NRX3A_HUMAN » Neurexin-3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
NRX3A_HUMAN » Neurexin-3 » Neurexin III-alpha;Neurexin-3-alpha;
Hydrophobic Thickness 32.0 ± 2.4 Å
Tilt Angle 4 ± 2°
ΔGtransfer -46.5 kcal/mol
ΔGfold -25.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 1568-1592 (1563-1595)
Pathways

Cell adhesion molecules (KEGG)

PDB none
OPM none
Complexes none
Interactions

NLGN1, Complex: NLGN1:NRX3A.NRX3B, PubMed

NLGN2, Complex: NLGN2:NRX3A.NRX3B, PubMed

NLGN3, Complex: NRX3A.NRX3B:NLGN3, PubMed

NRX3B, Complex: NRX3A:NRX3B

Domains

AA: 55-184, PDBID: 3ASI, Subunit A, Seq Identity:28%, Laminin G domain

AA: 287-413, PDBID: 2H0B, Subunit B, Seq Identity:83%, Laminin G domain

AA: 475-619, PDBID: 3POY, Subunit A, Seq Identity:74%, Laminin G domain

AA: 647-678, PDBID: 3POY, Subunit A, Seq Identity:63%, EGF-like domain

AA: 713-843, PDBID: 2R16, Subunit A, Seq Identity:79%, Laminin G domain

AA: 899-1027, PDBID: 3ASI, Subunit A, Seq Identity:64%, Laminin G domain

AA: 1122-1241, PDBID: 3MW4, Subunit B, Seq Identity:76%, Laminin G domain

AA: 1560-1625, PDBID: 1EJP, Subunit B, Seq Identity:15%, Syndecan domain

UniProt annotation for NRX3A_HUMAN » Neurexin-3
FUNCTION: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.

SUBUNIT: The laminin G-like domain 2 binds to NXPH1. Specific isoforms bind to alpha-dystroglycan. The cytoplasmic C-terminal region binds to CASK (By similarity).

TISSUE SPECIFICITY: Expressed in the blood vessel walls (at protein level). Highly expressed in brain, lung, and pancreas; a lower level of expression is detectable in heart, placenta, liver, and kidney, whereas no expression can be observed in skeletal muscle. Isoform 4a is heart-specific.

UniProt features for NRX3A_HUMAN » Neurexin-3
SIGNAL 1 27 By similarity.
CHAIN 28 1643 Neurexin-3.
DOMAIN 28 202 Laminin G-like 1.
DOMAIN 198 235 EGF-like 1.
DOMAIN 258 440 Laminin G-like 2.
DOMAIN 447 639 Laminin G-like 3.
DOMAIN 643 680 EGF-like 2.
DOMAIN 685 857 Laminin G-like 4.
DOMAIN 871 1046 Laminin G-like 5.
DOMAIN 1049 1086 EGF-like 3.
DOMAIN 1090 1260 Laminin G-like 6.
DISULFID 202 213 By similarity.
DISULFID 207 222 By similarity.
DISULFID 224 234 By similarity.
DISULFID 404 440 By similarity.
DISULFID 610 639 By similarity.
DISULFID 647 658 By similarity.
DISULFID 652 667 By similarity.
DISULFID 669 679 By similarity.
DISULFID 1018 1046 By similarity.
DISULFID 1053 1064 By similarity.
DISULFID 1058 1073 By similarity.
DISULFID 1075 1085 By similarity.
Amino Acid Sequence for NRX3A_HUMAN » Neurexin-3
MSSTLHSVFF TLKVSILLGS LLGLCLGLEF MGLPNQWARY LRWDASTRSD LSFQFKTNVS TGLLLYLDDG GVCDFLCLSL VDGRVQLRFS MDCAETAVLS NKQVNDSSWH FLMVSRDRLR TVLMLDGEGQ SGELQPQRPY MDVVSDLFLG GVPTDIRPSA LTLDGVQAMP GFKGLILDLK YGNSEPRLLG SRGVQMDAEG PCGERPCENG GICFLLDGHP TCDCSTTGYG GKLCSEDVSQ DPGLSHLMMS EQAREENVAT FRGSEYLCYD LSQNPIQSSS DEITLSFKTW QRNGLILHTG KSADYVNLAL KDGAVSLVIN LGSGAFEAIV EPVNGKFNDN AWHDVKVTRN LRQVTISVDG ILTTTGYTQE DYTMLGSDDF FYVGGSPSTA DLPGSPVSNN FMGCLKEVVY KNNDIRLELS RLARIADTKM KIYGEVVFKC ENVATLDPIN FETPEAYISL PKWNTKRMGS ISFDFRTTEP NGLILFTHGK PQERKDARSQ KNTKVDFFAV ELLDGNLYLL LDMGSGTIKV KATQKKANDG EWYHVDIQRD GRSGTISVNS RRTPFTASGE SEILDLEGDM YLGGLPENRA GLILPTELWT AMLNYGYVGC IRDLFIDGRS KNIRQLAEMQ NAAGVKSSCS RMSAKQCDSY PCKNNAVCKD GWNRFICDCT GTGYWGRTCE REASILSYDG SMYMKIIMPM VMHTEAEDVS FRFMSQRAYG LLVATTSRDS ADTLRLELDG GRVKLMVNLD CIRINCNSSK GPETLYAGQK LNDNEWHTVR VVRRGKSLKL TVDDDVAEGT MVGDHTRLEF HNIETGIMTE KRYISVVPSS FIGHLQSLMF NGLLYIDLCK NGDIDYCELK ARFGLRNIIA DPVTFKTKSS YLSLATLQAY TSMHLFFQFK TTSPDGFILF NSGDGNDFIA VELVKGYIHY VFDLGNGPNV IKGNSDRPLN DNQWHNVVIT RDNSNTHSLK VDTKVVTQVI NGAKNLDLKG DLYMAGLAQG MYSNLPKLVA SRDGFQGCLA SVDLNGRLPD LINDALHRSG QIERGCEGPS TTCQEDSCAN QGVCMQQWEG FTCDCSMTSY SGNQCNDPGA TYIFGKSGGL ILYTWPANDR PSTRSDRLAV GFSTTVKDGI LVRIDSAPGL GDFLQLHIEQ GKIGVVFNIG TVDISIKEER TPVNDGKYHV VRFTRNGGNA TLQVDNWPVN EHYPTGRQLT IFNTQAQIAI GGKDKGRLFQ GQLSGLYYDG LKVLNMAAEN NPNIKINGSV RLVGEVPSIL GTTQTTSMPP EMSTTVMETT TTMATTTTRK NRSTASIQPT SDDLVSSAEC SSDDEDFVEC EPSTTGGELV IPLLVEDPLA TPPIATRAPS ITLPPTFRPL LTIIETTKDS LSMTSEAGLP CLSDQGSDGC DDDGLVISGY GSGETFDSNL PPTDDEDFYT TFSLVTDKSL STSIFEGGYK AHAPKWESKD FRPNKVSETS RTTTTSLSPE LIRFTASSSS GMVPKLPAGK MNNRDLKPQP DIVLLPLPTA YELDSTKLKS PLITSPMFRN VPTANPTEPG IRRVPGASEV IRESSSTTGM VVGIVAAAAL CILILLYAMY KYRNRDEGSY QVDETRNYIS NSAQSNGTLM KEKQQSSKSG HKKQKNKDRE YYV