NRX2B_HUMAN » Neurexin-2-beta

NRX2B_HUMAN » Neurexin-2-beta
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
NRX2B_HUMAN » Neurexin-2-beta » Neurexin II-beta;
Hydrophobic Thickness 32.0 ± 2.4 Å
Tilt Angle 4 ± 2°
ΔGtransfer -46.5 kcal/mol
ΔGfold -25.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 590-614 (585-617)
Pathways

Cell adhesion molecules (KEGG)

PDB none
OPM none
Complexes none
Interactions

NRX2A, Complex: NRX2A:NRX2B

Domains

AA: 123-272, PDBID: 1C4R, Subunit A, Seq Identity:85%, Laminin G domain

AA: 582-641, PDBID: 1EJP, Subunit B, Seq Identity:17%, Syndecan domain

UniProt annotation for NRX2B_HUMAN » Neurexin-2-beta
FUNCTION: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion.

SUBUNIT: The cytoplasmic C-terminal region binds to CASK. Specific isoforms bind alpha-dystroglycan and neuroligins NLGN1, NLGN2 and NLGN3 (By similarity). Interacts with CBLN1, CBLN2 and, less avidly, with CBLN4 (By similarity).

DOMAIN: Alternative splicing in the laminin G-like domain regulates binding to alpha-dystroglycan.

UniProt features for NRX2B_HUMAN » Neurexin-2-beta
SIGNAL 1 50 By similarity.
CHAIN 51 666 Neurexin-2-beta.
DOMAIN 91 299 Laminin G-like.
Amino Acid Sequence for NRX2B_HUMAN » Neurexin-2-beta
MPPGGSGPGG CPRRPPALAG PLPPPPPPPP PPLLPLLPLL LLLLLGAAEG ARVSSSLSTT HHVHHFHSKH GTVPIAINRM PFLTRGGHAG TTYIFGKGGA LITYTWPPND RPSTRMDRLA VGFSTHQRSA VLVRVDSASG LGDYLQLHID QGTVGVIFNV GTDDITIDEP NAIVSDGKYH VVRFTRSGGN ATLQVDSWPV NERYPAGNFD NERLAIARQR IPYRLGRVVD EWLLDKGRQL TIFNSQAAIK IGGRDQGRPF QGQVSGLYYN GLKVLALAAE SDPNVRTEGH LRLVGEGPSV LLSAETTATT LLADMATTIM ETTTTMATTT TRRGRSPTLR DSTTQNTDDL LVASAECPSD DEDLEECEPS TGGELILPII TEDSLDPPPV ATRSPFVPPP PTFYPFLTGV GATQDTLPPP AARRPPSGGP CQAERDDSDC EEPIEASGFA SGEVFDSSLP PTDDEDFYTT FPLVTDRTTL LSPRKPAPRP NLRTDGATGA PGVLFAPSAP APNLPAGKMN HRDPLQPLLE NPPLGPGAPT SFEPRRPPPL RPGVTSAPGF PHLPTANPTG PGERGPPGAV EVIRESSSTT GMVVGIVAAA ALCILILLYA MYKYRNRDEG SYQVDQSRNY ISNSAQSNGA VVKEKAPAAP KTPSKAKKNK DKEYYV