NRX2A_HUMAN » Neurexin-2

NRX2A_HUMAN » Neurexin-2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
NRX2A_HUMAN » Neurexin-2 » Neurexin II-alpha;Neurexin-2-alpha;
Hydrophobic Thickness 32.0 ± 2.4 Å
Tilt Angle 4 ± 2°
ΔGtransfer -46.5 kcal/mol
ΔGfold -25.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 1636-1660 (1631-1663)
Pathways

Cell adhesion molecules (KEGG)

PDB none
OPM none
Complexes none
Interactions

NLGN1, Complex: NLGN1:NRX2A.NRX2B, PubMed

NLGN2, Complex: NRX2A.NRX2B:NLGN2, PubMed

NLGN3, Complex: NRX2A.NRX2B:NLGN3, PubMed

NRX2B, Complex: NRX2A:NRX2B

Domains

AA: 57-187, PDBID: 3SH4, Subunit A, Seq Identity:25%, Laminin G domain

AA: 318-459, PDBID: 2H0B, Subunit B, Seq Identity:91%, Laminin G domain

AA: 521-666, PDBID: 3POY, Subunit A, Seq Identity:62%, Laminin G domain

AA: 760-890, PDBID: 2R16, Subunit A, Seq Identity:70%, Laminin G domain

AA: 946-1074, PDBID: 3ASI, Subunit A, Seq Identity:61%, Laminin G domain

AA: 1169-1318, PDBID: 1C4R, Subunit A, Seq Identity:85%, Laminin G domain

AA: 1628-1687, PDBID: 1EJP, Subunit B, Seq Identity:17%, Syndecan domain

UniProt annotation for NRX2A_HUMAN » Neurexin-2
FUNCTION: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.

SUBUNIT: The laminin G-like domain 1 binds to NXPH1. Specific isoforms bind to alpha-dystroglycan. Interacts with INADL (By similarity). Interacts with CBLN1, CBLN2 and, less avidly, with CBLN4 (By similarity).

TISSUE SPECIFICITY: Predominantly expressed in brain.

UniProt features for NRX2A_HUMAN » Neurexin-2
SIGNAL 1 28 Potential.
CHAIN 29 1712 Neurexin-2.
DOMAIN 29 206 Laminin G-like 1.
DOMAIN 202 242 EGF-like 1.
DOMAIN 289 486 Laminin G-like 2.
DOMAIN 493 686 Laminin G-like 3.
DOMAIN 690 727 EGF-like 2.
DOMAIN 732 904 Laminin G-like 4.
DOMAIN 918 1093 Laminin G-like 5.
DOMAIN 1096 1133 EGF-like 3.
DOMAIN 1137 1345 Laminin G-like 6.
DISULFID 206 219 By similarity.
DISULFID 213 229 By similarity.
DISULFID 231 241 By similarity.
DISULFID 450 486 By similarity.
DISULFID 657 686 By similarity.
DISULFID 694 705 By similarity.
DISULFID 699 714 By similarity.
DISULFID 716 726 By similarity.
DISULFID 1065 1093 By similarity.
DISULFID 1100 1111 By similarity.
DISULFID 1105 1120 By similarity.
DISULFID 1122 1132 By similarity.
Amino Acid Sequence for NRX2A_HUMAN » Neurexin-2
MASGSRWRPT PPPLLLLLLL ALAARADGLE FGGGPGQWAR YARWAGAASS GELSFSLRTN ATRALLLYLD DGGDCDFLEL LLVDGRLRLR FTLSCAEPAT LQLDTPVADD RWHMVLLTRD ARRTALAVDG EARAAEVRSK RREMQVASDL FVGGIPPDVR LSALTLSTVK YEPPFRGLLA NLKLGERPPA LLGSQGLRGA TADPLCAPAR NPCANGGLCT VLAPGEVGCD CSHTGFGGKF CSEEEHPMEG PAHLTLNSEV GSLLFSEGGA GRGGAGDVHQ PTKGKEEFVA TFKGNEFFCY DLSHNPIQSS TDEITLAFRT LQRNGLMLHT GKSADYVNLS LKSGAVWLVI NLGSGAFEAL VEPVNGKFND NAWHDVRVTR NLRQHAGIGH AMVNKLHYLV TISVDGILTT TGYTQEDYTM LGSDDFFYIG GSPNTADLPG SPVSNNFMGC LKDVVYKNND FKLELSRLAK EGDPKMKLQG DLSFRCEDVA ALDPVTFESP EAFVALPRWS AKRTGSISLD FRTTEPNGLL LFSQGRRAGG GAGSHSSAQR ADYFAMELLD GHLYLLLDMG SGGIKLRASS RKVNDGEWCH VDFQRDGRKG SISVNSRSTP FLATGDSEIL DLESELYLGG LPEGGRVDLP LPPEVWTAAL RAGYVGCVRD LFIDGRSRDL RGLAEAQGAV GVAPFCSRET LKQCASAPCR NGGVCREGWN RFICDCIGTG FLGRVCEREA TVLSYDGSMY MKIMLPNAMH TEAEDVSLRF MSQRAYGLMM ATTSRESADT LRLELDGGQM KLTVNLDCLR VGCAPSKGPE TLFAGHKLND NEWHTVRVVR RGKSLQLSVD NVTVEGQMAG AHMRLEFHNI ETGIMTERRF ISVVPSNFIG HLSGLVFNGQ PYMDQCKDGD ITYCELNARF GLRAIVADPV TFKSRSSYLA LATLQAYASM HLFFQFKTTA PDGLLLFNSG NGNDFIVIEL VKGYIHYVFD LGNGPSLMKG NSDKPVNDNQ WHNVVVSRDP GNVHTLKIDS RTVTQHSNGA RNLDLKGELY IGGLSKNMFS NLPKLVASRD GFQGCLASVD LNGRLPDLIA DALHRIGQVE RGCDGPSTTC TEESCANQGV CLQQWDGFTC DCTMTSYGGP VCNDPGTTYI FGKGGALITY TWPPNDRPST RMDRLAVGFS THQRSAVLVR VDSASGLGDY LQLHIDQGTV GVIFNVGTDD ITIDEPNAIV SDGKYHVVRF TRSGGNATLQ VDSWPVNERY PAGNFDNERL AIARQRIPYR LGRVVDEWLL DKGRQLTIFN SQAAIKIGGR DQGRPFQGQV SGLYYNGLKV LALAAESDPN VRTEGHLRLV GEGPSVLLSA ETTATTLLAD MATTIMETTT TMATTTTRRG RSPTLRDSTT QNTDDLLVAS AECPSDDEDL EECEPSTGGE LILPIITEDS LDPPPVATRS PFVPPPPTFY PFLTGVGATQ DTLPPPAARR PPSGGPCQAE RDDSDCEEPI EASGFASGEV FDSSLPPTDD EDFYTTFPLV TDRTTLLSPR KPAPRPNLRT DGATGAPGVL FAPSAPAPNL PAGKMNHRDP LQPLLENPPL GPGAPTSFEP RRPPPLRPGV TSAPGFPHLP TANPTGPGER GPPGAVEVIR ESSSTTGMVV GIVAAAALCI LILLYAMYKY RNRDEGSYQV DQSRNYISNS AQSNGAVVKE KAPAAPKTPS KAKKNKDKEY YV