NRP2_HUMAN » Neuropilin-2

NRP2_HUMAN » Neuropilin-2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
NRP2_HUMAN » Neuropilin-2 » Vascular endothelial cell growth factor 165 receptor 2;
Hydrophobic Thickness 42.0 ± 2.2 Å
Tilt Angle 1 ± 0°
ΔGtransfer -32.7 kcal/mol
ΔGfold -15.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 864-892 (864-895)
Pathways

Developmental Biology (Reactome)

Signal Transduction (Reactome)

PDB 2qqj (275-595), 2qqo (A/B=145-595), 2qqk (A=23-595), 2qql (A=23-595)
OPM none
Complexes none
Interactions

NRP1, Complex: NRP1:NRP2, PubMed

NRP2, Complex: Homodimer of neuropilin-2, PDBID: 2QQO

RYK, Complex: NRP2:RYK, PubMed

SEM4F, Complex: NRP2:SEM4F, PubMed

TGFR2, Complex: TGFR2:NRP2

VGFR1, Complex: NRP2:VGFR1, PubMed

VGFR3, Complex: VGFR3:NRP2

Domains

AA: 28-139, PDBID: 2QQK, Subunit A, Seq Identity:100%, CUB domain

AA: 149-264, PDBID: 2QQK, Subunit A, Seq Identity:100%, CUB domain

AA: 292-424, PDBID: 2QQJ, Subunit A, Seq Identity:100%, F5/8 type C domain

AA: 449-589, PDBID: 2QQJ, Subunit A, Seq Identity:100%, F5/8 type C domain

AA: 646-801, PDBID: 4GWM, Subunit A, Seq Identity:22%, MAM domain, meprin/A5/mu

AA: 850-931, C-terminal domain of neuropilin glycoprotein

UniProt annotation for NRP2_HUMAN » Neuropilin-2
FUNCTION: High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.

SUBUNIT: Heterodimer with NRP1. Binds PLXNB1.

DOMAIN: The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding.

UniProt features for NRP2_HUMAN » Neuropilin-2
SIGNAL 1 20 Or 22 (Potential).
CHAIN 21 931 Neuropilin-2.
DOMAIN 28 142 CUB 1.
DOMAIN 149 267 CUB 2.
DOMAIN 277 427 F5/8 type C 1.
DOMAIN 434 592 F5/8 type C 2.
DOMAIN 642 802 MAM.
DISULFID 28 55
DISULFID 83 105
DISULFID 149 175
DISULFID 208 230
DISULFID 277 427
DISULFID 434 592
Amino Acid Sequence for NRP2_HUMAN » Neuropilin-2
MDMFPLTWVF LALYFSRHQV RGQPDPPCGG RLNSKDAGYI TSPGYPQDYP SHQNCEWIVY APEPNQKIVL NFNPHFEIEK HDCKYDFIEI RDGDSESADL LGKHCGNIAP PTIISSGSML YIRFTSDYAR QGAGFSLRYE IFKTGSEDCS KNFTSPNGTI ESPGFPEKYP HNLDCTFTIL AKPKMEIILQ FLIFDLEHDP LQVGEGDCKY DWLDIWDGIP HVGPLIGKYC GTKTPSELRS STGILSLTFH TDMAVAKDGF SARYYLVHQE PLENFQCNVP LGMESGRIAN EQISASSTYS DGRWTPQQSR LHGDDNGWTP NLDSNKEYLQ VDLRFLTMLT AIATQGAISR ETQNGYYVKS YKLEVSTNGE DWMVYRHGKN HKVFQANNDA TEVVLNKLHA PLLTRFVRIR PQTWHSGIAL RLELFGCRVT DAPCSNMLGM LSGLIADSQI SASSTQEYLW SPSAARLVSS RSGWFPRIPQ AQPGEEWLQV DLGTPKTVKG VIIQGARGGD SITAVEARAF VRKFKVSYSL NGKDWEYIQD PRTQQPKLFE GNMHYDTPDI RRFDPIPAQY VRVYPERWSP AGIGMRLEVL GCDWTDSKPT VETLGPTVKS EETTTPYPTE EEATECGENC SFEDDKDLQL PSGFNCNFDF LEEPCGWMYD HAKWLRTTWA SSSSPNDRTF PDDRNFLRLQ SDSQREGQYA RLISPPVHLP RSPVCMEFQY QATGGRGVAL QVVREASQES KLLWVIREDQ GGEWKHGRII LPSYDMEYQI VFEGVIGKGR SGEIAIDDIR ISTDVPLENC MEPISAFAGE NFKVDIPEIH EREGYEDEID DEYEVDWSNS SSATSGSGAP STDKEKSWLY TLDPILITII AMSSLGVLLG ATCAGLLLYC TCSYSGLSSR SCTTLENYNF ELYDGLKHKV KMNHQKCCSE A