NRG4_HUMAN » Pro-neuregulin-4, membrane-bound isoform

NRG4_HUMAN » Pro-neuregulin-4, membrane-bound isoform
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
NRG4_HUMAN » Pro-neuregulin-4, membrane-bound isoform » Pro-NRG4;
Hydrophobic Thickness 33.0 ± 2.0 Å
Tilt Angle 9 ± 9°
ΔGtransfer -25.7 kcal/mol
ΔGfold -19.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 61-82 (61-85)
Pathways

ErbB signaling pathway (KEGG)

Immune System (Reactome)

Signal Transduction (Reactome)

PDB none
OPM none
Complexes none
Interactions

CREB3, Complex: NRG4:CREB3

ERBB4, Complex: NRG4:ERBB4, PubMed

FATE1, Complex: NRG4:FATE1

Domains

AA: 9-44, PDBID: 1PFX, Subunit L, Seq Identity:42%, EGF-like domain

UniProt annotation for NRG4_HUMAN » Pro-neuregulin-4, membrane-bound isoform
FUNCTION: Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity).

SUBUNIT: Interacts with ERBB4.

DOMAIN: The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity).

DOMAIN: ERBB receptor binding is elicited entirely by the EGF-like domain.

UniProt features for NRG4_HUMAN » Pro-neuregulin-4, membrane-bound isoform
CHAIN 1 115 Pro-neuregulin-4, membrane-bound isoform.
CHAIN 1 61 Neuregulin-4.
DOMAIN 5 46 EGF-like.
DISULFID 9 23 By similarity.
DISULFID 17 34 By similarity.
DISULFID 36 45 By similarity.
Amino Acid Sequence for NRG4_HUMAN » Pro-neuregulin-4, membrane-bound isoform
MPTDHEEPCG PSHKSFCLNG GLCYVIPTIP SPFCRCVENY TGARCEEVFL PGSSIQTKSN LFEAFVALAV LVTLIIGAFY FLCRKGHFQR ASSVQYDINL VETSSTSAHH SHEQH