NRG3_HUMAN » Pro-neuregulin-3, membrane-bound isoform

NRG3_HUMAN » Pro-neuregulin-3, membrane-bound isoform
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
NRG3_HUMAN » Pro-neuregulin-3, membrane-bound isoform » Pro-NRG3;
Hydrophobic Thickness 35.2 ± 2.0 Å
Tilt Angle 8 ± 4°
ΔGtransfer -24.5 kcal/mol
ΔGfold -19.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 360-384 (354-389)
Pathways

ErbB signaling pathway (KEGG)

Immune System (Reactome)

Signal Transduction (Reactome)

PDB none
OPM none
Complexes none
Interactions

ERBB4, Complex: ERBB4:NRG3, PubMed

Domains

AA: 353-512, PDBID: 1HAE, Subunit A, Seq Identity:8%, Neuregulin family

UniProt annotation for NRG3_HUMAN » Pro-neuregulin-3, membrane-bound isoform
FUNCTION: Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.

SUBUNIT: Interacts with ERBB4.

TISSUE SPECIFICITY: Highly expressed in most regions of the brain with the exception of corpus callosum. Expressed at lower level in testis. Not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes.

DEVELOPMENTAL STAGE: Isoform 3 is expressed in fetal brain but not in other fetal tissues.

DOMAIN: The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity).

DOMAIN: ERBB receptor binding is elicited entirely by the EGF-like domain.

UniProt features for NRG3_HUMAN » Pro-neuregulin-3, membrane-bound isoform
CHAIN 1 720 Pro-neuregulin-3, membrane-bound isoform.
CHAIN 1 359 Neuregulin-3.
DOMAIN 286 329 EGF-like.
DISULFID 290 304 By similarity.
DISULFID 298 317 By similarity.
DISULFID 319 328 By similarity.
Amino Acid Sequence for NRG3_HUMAN » Pro-neuregulin-3, membrane-bound isoform
MSEGAAAASP PGAASAAAAS AEEGTAAAAA AAAAGGGPDG GGEGAAEPPR ELRCSDCIVW NRQQTWLCVV PLFIGFIGLG LSLMLLKWIV VGSVKEYVPT DLVDSKGMGQ DPFFLSKPSS FPKAMETTTT TTSTTSPATP SAGGAASSRT PNRISTRLTT ITRAPTRFPG HRVPIRASPR STTARNTAAP ATVPSTTAPF FSSSTLGSRP PVPGTPSTQA MPSWPTAAYA TSSYLHDSTP SWTLSPFQDA ASSSSSSSSS ATTTTPETST SPKFHTTTYS TERSEHFKPC RDKDLAYCLN DGECFVIETL TGSHKHCRCK EGYQGVRCDQ FLPKTDSILS DPTDHLGIEF MESEEVYQRQ VLSISCIIFG IVIVGMFCAA FYFKSKKQAK QIQEQLKVPQ NGKSYSLKAS STMAKSENLV KSHVQLQNYS KVERHPVTAL EKMMESSFVG PQSFPEVPSP DRGSQSVKHH RSLSSCCSPG QRSGMLHRNA FRRTPPSPRS RLGGIVGPAY QQLEESRIPD QDTIPCQGIE VRKTISHLPI QLWCVERPLD LKYSSSGLKT QRNTSINMQL PSRETNPYFN SLEQKDLVGY SSTRASSVPI IPSVGLEETC LQMPGISEVK SIKWCKNSYS ADVVNVSIPV SDCLIAEQQE VKILLETVQE QIRILTDARR SEDYELASVE TEDSASENTA FLPLSPTAKS EREAQFVLRN EIQRDSALTK