NRG2_HUMAN » Pro-neuregulin-2, membrane-bound isoform

NRG2_HUMAN » Pro-neuregulin-2, membrane-bound isoform
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
NRG2_HUMAN » Pro-neuregulin-2, membrane-bound isoform » Pro-NRG2;
Hydrophobic Thickness 32.8 ± 3.2 Å
Tilt Angle 2 ± 3°
ΔGtransfer -39.5 kcal/mol
ΔGfold -20.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 406-429 (398-434)
Pathways

ErbB signaling pathway (KEGG)

Immune System (Reactome)

Signal Transduction (Reactome)

PDB none
OPM none
Complexes none
Interactions

ERBB3, Complex: NRG2:ERBB3, PubMed

ERBB4, Complex: NRG2:ERBB4, PubMed

Domains

AA: 238-328, PDBID: 3S97, Subunit D, Seq Identity:35%, Immunoglobulin I-set domain

AA: 398-837, PDBID: 1HAE, Subunit A, Seq Identity:39%, Neuregulin family

UniProt annotation for NRG2_HUMAN » Pro-neuregulin-2, membrane-bound isoform
FUNCTION: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.

SUBUNIT: Interacts with ERBB3 and ERBB4.

TISSUE SPECIFICITY: Restricted to the cerebellum in the adult.

DOMAIN: The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity).

DOMAIN: ERBB receptor binding is elicited entirely by the EGF-like domain.

UniProt features for NRG2_HUMAN » Pro-neuregulin-2, membrane-bound isoform
PROPEP 1 111 By similarity.
CHAIN 112 850 Pro-neuregulin-2, membrane-bound isoform.
CHAIN 112 404 Neuregulin-2.
DOMAIN 237 332 Ig-like C2-type.
DOMAIN 341 382 EGF-like.
DISULFID 257 311 By similarity.
DISULFID 345 359 By similarity.
DISULFID 353 370 By similarity.
DISULFID 372 381 By similarity.
Amino Acid Sequence for NRG2_HUMAN » Pro-neuregulin-2, membrane-bound isoform
MRQVCCSALP PPPLEKGRCS SYSDSSSSSS ERSSSSSSSS SESGSSSRSS SNNSSISRPA APPEPRPQQQ PQPRSPAARR AAARSRAAAA GGMRRDPAPG FSMLLFGVSL ACYSPSLKSV QDQAYKAPVV VEGKVQGLVP AGGSSSNSTR EPPASGRVAL VKVLDKWPLR SGGLQREQVI SVGSCVPLER NQRYIFFLEP TEQPLVFKTA FAPLDTNGKN LKKEVGKILC TDCATRPKLK KMKSQTGQVG EKQSLKCEAA AGNPQPSYRW FKDGKELNRS RDIRIKYGNG RKNSRLQFNK VKVEDAGEYV CEAENILGKD TVRGRLYVNS VSTTLSSWSG HARKCNETAK SYCVNGGVCY YIEGINQLSC KCPNGFFGQR CLEKLPLRLY MPDPKQKAEE LYQKRVLTIT GICVALLVVG IVCVVAYCKT KKQRKQMHNH LRQNMCPAHQ NRSLANGPSH PRLDPEEIQM ADYISKNVPA TDHVIRRETE TTFSGSHSCS PSHHCSTATP TSSHRHESHT WSLERSESLT SDSQSGIMLS SVGTSKCNSP ACVEARARRA AAYNLEERRR ATAPPYHDSV DSLRDSPHSE RYVSALTTPA RLSPVDFHYS LATQVPTFEI TSPNSAHAVS LPPAAPISYR LAEQQPLLRH PAPPGPGPGP GPGPGPGADM QRSYDSYYYP AAGPGPRRGT CALGGSLGSL PASPFRIPED DEYETTQECA PPPPPRPRAR GASRRTSAGP RRWRRSRLNG LAAQRARAAR DSLSLSSGSG GGSASASDDD ADDADGALAA ESTPFLGLRG AHDALRSDSP PLCPAADSRT YYSLDSHSTR ASSRHSRGPP PRAKQDSAPL