NRCAM_HUMAN » Neuronal cell adhesion molecule

NRCAM_HUMAN » Neuronal cell adhesion molecule
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
NRCAM_HUMAN » Neuronal cell adhesion molecule » Nr-CAM; Neuronal surface protein Bravo;hBravo; NgCAM-related cell adhesion molecule;Ng-CAM-related;
Hydrophobic Thickness 34.0 ± 3.0 Å
Tilt Angle 5 ± 5°
ΔGtransfer -29.9 kcal/mol
ΔGfold -24.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 1168-1191 (1164-1194)
Pathways

Cell adhesion molecules (KEGG)

Developmental Biology (Reactome)

PDB 1uey (638-751), 1uen (839-950)
OPM none
Complexes none
Interactions

FRMD5, Complex: NRCAM:FRMD5

NFASC, Complex: NRCAM:NFASC, PubMed

PTPRB, Complex: NRCAM:PTPRB, PubMed

Domains

AA: 45-127, PDBID: 3P3Y, Subunit A, Seq Identity:52%, Immunoglobulin domain

AA: 274-357, PDBID: 1DJS, Subunit A, Seq Identity:36%, Immunoglobulin I-set domain

AA: 361-436, PDBID: 3P3Y, Subunit A, Seq Identity:49%, Immunoglobulin domain

AA: 454-542, PDBID: 2EDJ, Subunit A, Seq Identity:31%, Immunoglobulin I-set domain

AA: 546-633, PDBID: 2V9Q, Subunit A, Seq Identity:37%, Immunoglobulin I-set domain

AA: 648-733, PDBID: 1UEY, Subunit A, Seq Identity:100%, Fibronectin type III domain

AA: 748-833, PDBID: 1UEY, Subunit A, Seq Identity:100%, Fibronectin type III domain

AA: 847-940, PDBID: 1UEN, Subunit A, Seq Identity:100%, Fibronectin type III domain

AA: 953-1040, PDBID: 1X5L, Subunit A, Seq Identity:32%, Fibronectin type III domain

AA: 1068-1148, PDBID: 1FNA, Subunit A, Seq Identity:29%, Fibronectin type III domain

AA: 1191-1280, Bravo-like intracellular region

UniProt annotation for NRCAM_HUMAN » Neuronal cell adhesion molecule
FUNCTION: Cell adhesion, ankyrin-binding protein involved in neuron-neuron adhesion. May play a role in the molecular assembly of the nodes of Ranvier (By similarity).

SUBUNIT: Probable constituent of a neurofascin/NRCAM/ankyrin-G complex. Interacts with GLDN/gliomedin (By similarity). Interacts with MYOC.

TISSUE SPECIFICITY: Detected in all the examined tissues. In the brain it was detected in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus and thalamus.

UniProt features for NRCAM_HUMAN » Neuronal cell adhesion molecule
SIGNAL 1 24 Potential.
CHAIN 25 1304 Neuronal cell adhesion molecule.
DOMAIN 46 134 Ig-like 1.
DOMAIN 141 235 Ig-like 2.
DOMAIN 267 356 Ig-like 3.
DOMAIN 361 448 Ig-like 4.
DOMAIN 454 541 Ig-like 5.
DOMAIN 545 632 Ig-like 6.
DOMAIN 647 739 Fibronectin type-III 1.
DOMAIN 746 840 Fibronectin type-III 2.
DOMAIN 845 947 Fibronectin type-III 3.
DOMAIN 952 1046 Fibronectin type-III 4.
DOMAIN 1061 1153 Fibronectin type-III 5.
DISULFID 68 123 Potential.
DISULFID 167 218 Potential.
DISULFID 292 340 Potential.
DISULFID 382 432 Potential.
DISULFID 476 525 Potential.
DISULFID 567 616 Potential.
Amino Acid Sequence for NRCAM_HUMAN » Neuronal cell adhesion molecule
MQLKIMPKKK RLSAGRVPLI LFLCQMISAL EVPLDPKLLE DLVQPPTITQ QSPKDYIIDP RENIVIQCEA KGKPPPSFSW TRNGTHFDID KDPLVTMKPG TGTLIINIMS EGKAETYEGV YQCTARNERG AAVSNNIVVR PSRSPLWTKE KLEPITLQSG QSLVLPCRPP IGLPPPIIFW MDNSFQRLPQ SERVSQGLNG DLYFSNVLPE DTREDYICYA RFNHTQTIQQ KQPISVKVIS VDELNDTIAA NLSDTEFYGA KSSRERPPTF LTPEGNASNK EELRGNVLSL ECIAEGLPTP IIYWAKEDGM LPKNRTVYKN FEKTLQIIHV SEADSGNYQC IAKNALGAIH HTISVRVKAA PYWITAPQNL VLSPGEDGTL ICRANGNPKP RISWLTNGVP IEIAPDDPSR KIDGDTIIFS NVQERSSAVY QCNASNEYGY LLANAFVNVL AEPPRILTPA NTLYQVIANR PALLDCAFFG SPLPTIEWFK GAKGSALHED IYVLHENGTL EIPVAQKDST GTYTCVARNK LGMAKNEVHL EIKDPTWIVK QPEYAVVQRG SMVSFECKVK HDHTLSLTVL WLKDNRELPS DERFTVDKDH LVVADVSDDD SGTYTCVANT TLDSVSASAV LSVVAPTPTP APVYDVPNPP FDLELTDQLD KSVQLSWTPG DDNNSPITKF IIEYEDAMHK PGLWHHQTEV SGTQTTAQLK LSPYVNYSFR VMAVNSIGKS LPSEASEQYL TKASEPDKNP TAVEGLGSEP DNLVITWKPL NGFESNGPGL QYKVSWRQKD GDDEWTSVVV ANVSKYIVSG TPTFVPYLIK VQALNDMGFA PEPAVVMGHS GEDLPMVAPG NVRVNVVNST LAEVHWDPVP LKSIRGHLQG YRIYYWKTQS SSKRNRRHIE KKILTFQGSK THGMLPGLEP FSHYTLNVRV VNGKGEGPAS PDRVFNTPEG VPSAPSSLKI VNPTLDSLTL EWDPPSHPNG ILTEYTLKYQ PINSTHELGP LVDLKIPANK TRWTLKNLNF STRYKFYFYA QTSAGSGSQI TEEAVTTVDE AGILPPDVGA GKVQAVNPRI SNLTAAAAET YANISWEYEG PEHVNFYVEY GVAGSKEEWR KEIVNGSRSF FGLKGLMPGT AYKVRVGAVG DSGFVSSEDV FETGPAMASR QVDIATQGWF IGLMCAVALL ILILLIVCFI RRNKGGKYPV KEKEDAHADP EIQPMKEDDG TFGEYSDAED HKPLKKGSRT PSDRTVKKED SDDSLVDYGE GVNGQFNEDG SFIGQYSGKK EKEPAEGNES SEAPSPVNAM NSFV