NR3L1_HUMAN » Natural cytotoxicity triggering receptor 3 ligand 1

NR3L1_HUMAN » Natural cytotoxicity triggering receptor 3 ligand 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
NR3L1_HUMAN » Natural cytotoxicity triggering receptor 3 ligand 1 » B7 homolog 6;B7-H6;
Hydrophobic Thickness 34.0 ± 2.1 Å
Tilt Angle 8 ± 6°
ΔGtransfer -26.1 kcal/mol
ΔGfold -13.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 265-287 (254-291)
Pathways none
PDB 3pv7 (25-262), 3pv6 (A=25-262)
OPM none
Complexes

NCTR3:NR3L1_HUMAN

Interactions

NCTR3, Complex: NCTR3:NR3L1, PDBID: 3PV6

RYK, Complex: NR3L1:RYK, PubMed

Domains

AA: 147-235, PDBID: 3PV6, Subunit A, Seq Identity:100%, Immunoglobulin C1-set domain

AA: 291-418, PDBID: 1MN8, Subunit B, Seq Identity:19%, Matrix protein (MA), p15

UniProt annotation for NR3L1_HUMAN » Natural cytotoxicity triggering receptor 3 ligand 1
FUNCTION: Triggers NCR3-dependent natural killer cell activation.

SUBUNIT: Monomer. Interacts specifically with NCR3, but not with other natural killer cell-activating receptors, including NCR1, NCR2 and KLRK1.

TISSUE SPECIFICITY: Not detected in any normal tissue tested. Expressed at the surface of several tumor cell lines including T and B-lymphomas, myeloid leukemias, melanomas, carcinomas and large T SV40 antigen-transformed cells (at protein level).

DOMAIN: The C-terminal part is similar to retroviral Gag protein. This putative protein seems to be the result of a fusion between an Ig-like domain-containing protein and a ERV.

UniProt features for NR3L1_HUMAN » Natural cytotoxicity triggering receptor 3 ligand 1
SIGNAL 1 24 Potential.
CHAIN 25 454 Natural cytotoxicity triggering receptor 3 ligand 1.
DOMAIN 27 138 Ig-like V-type.
DOMAIN 143 244 Ig-like C1-type.
REGION 59 62 Interaction with NCR3.
REGION 127 130 Interaction with NCR3.
REGION 291 429 Retroviral-Gag-like.
DISULFID 48 122
DISULFID 163 228
Amino Acid Sequence for NR3L1_HUMAN » Natural cytotoxicity triggering receptor 3 ligand 1
MTWRAAASTC AALLILLWAL TTEGDLKVEM MAGGTQITPL NDNVTIFCNI FYSQPLNITS MGITWFWKSL TFDKEVKVFE FFGDHQEAFR PGAIVSPWRL KSGDASLRLP GIQLEEAGEY RCEVVVTPLK AQGTVQLEVV ASPASRLLLD QVGMKENEDK YMCESSGFYP EAINITWEKQ TQKFPHPIEI SEDVITGPTI KNMDGTFNVT SCLKLNSSQE DPGTVYQCVV RHASLHTPLR SNFTLTAARH SLSETEKTDN FSIHWWPISF IGVGLVLLIV LIPWKKICNK SSSAYTPLKC ILKHWNSFDT QTLKKEHLIF FCTRAWPSYQ LQDGEAWPPE GSVNINTIQQ LDVFCRQEGK WSEVPYVQAF FALRDNPDLC QCCRIDPALL TVTSGKSIDD NSTKSEKQTP REHSDAVPDA PILPVSPIWE PPPATTSTTP VLSSQPPTLL LPLQ