NPTXR_HUMAN » Neuronal pentraxin receptor

NPTXR_HUMAN » Neuronal pentraxin receptor
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
NPTXR_HUMAN » Neuronal pentraxin receptor »
Hydrophobic Thickness 33.6 ± 3.6 Å
Tilt Angle 49 ± 4°
ΔGtransfer -28.3 kcal/mol
ΔGfold -19.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology In
TM Segments 2-28 (2-31)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 292-488, PDBID: 1B09, Subunit D, Seq Identity:25%, Pentaxin family

UniProt annotation for NPTXR_HUMAN » Neuronal pentraxin receptor
FUNCTION: May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.

SUBUNIT: Heteropentamer with NPTX1 and/or NPTX2. Also binds taipoxin-associated calcium-binding protein 49 (TCBP49/RCN2). Interacts with KLHL2 (By similarity).

UniProt features for NPTXR_HUMAN » Neuronal pentraxin receptor
CHAIN 1 500 Neuronal pentraxin receptor.
DOMAIN 296 500 Pentaxin.
Amino Acid Sequence for NPTXR_HUMAN » Neuronal pentraxin receptor
MKFLAVLLAA GMLAFLGAVI CIIASVPLAA SPARALPGGA DNASVASGAA ASPGPQRSLS ALHGAGGSAG PPALPGAPAA SAHPLPPGPL FSRFLCTPLA AACPSGAQQG DAAGAAPGER EELLLLQSTA EQLRQTALQQ EARIRADQDT IRELTGKLGR CESGLPRGLQ GAGPRRDTMA DGPWDSPALI LELEDAVRAL RDRIDRLEQE LPARVNLSAA PAPVSAVPTG LHSKMDQLEG QLLAQVLALE KERVALSHSS RRQRQEVEKE LDVLQGRVAE LEHGSSAYSP PDAFKISIPI RNNYMYARVR KALPELYAFT ACMWLRSRSS GTGQGTPFSY SVPGQANEIV LLEAGHEPME LLINDKVAQL PLSLKDNGWH HICIAWTTRD GLWSAYQDGE LQGSGENLAA WHPIKPHGIL ILGQEQDTLG GRFDATQAFV GDIAQFNLWD HALTPAQVLG IANCTAPLLG NVLPWEDKLV EAFGGATKAA FDVCKGRAKA