NPTN_HUMAN » Neuroplastin

NPTN_HUMAN » Neuroplastin
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
NPTN_HUMAN » Neuroplastin » Stromal cell-derived receptor 1;SDR-1;
Hydrophobic Thickness 33.2 ± 2.0 Å
Tilt Angle 6 ± 3°
ΔGtransfer -28.8 kcal/mol
ΔGfold -16.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 340-361 (340-365)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 33-120, PDBID: 3QQN, Subunit B, Seq Identity:38%, Immunoglobulin domain

AA: 147-221, PDBID: 2WV3, Subunit A, Seq Identity:87%, Immunoglobulin domain

AA: 237-320, PDBID: 2WV3, Subunit A, Seq Identity:78%, Immunoglobulin domain

UniProt annotation for NPTN_HUMAN » Neuroplastin
FUNCTION: Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity (By similarity).

TISSUE SPECIFICITY: Isoform 1 is ubiquitously expressed. Isoform 2 is expressed in brain cortex and cerebellum (at protein level).

DOMAIN: Some isoforms lack the first Ig-like domain which may confer homophilic adhesion activity. However, they can bind and activate FGFR1 (By similarity).

UniProt features for NPTN_HUMAN » Neuroplastin
SIGNAL 1 28
CHAIN 29 398 Neuroplastin.
DOMAIN 29 134 Ig-like 1.
DOMAIN 148 235 Ig-like 2.
DOMAIN 238 329 Ig-like 3.
REGION 149 161 Narpin; mediates binding with FGFR1 and has antidepressant-like activity (By similarity).
DISULFID 52 116 By similarity.
DISULFID 170 218 By similarity.
DISULFID 259 316 By similarity.
Amino Acid Sequence for NPTN_HUMAN » Neuroplastin
MSGSSLPSAL ALSLLLVSGS LLPGPGAAQN AGFVKSPMSE TKLTGDAFEL YCDVVGSPTP EIQWWYAEVN RAESFRQLWD GARKRRVTVN TAYGSNGVSV LRITRLTLED SGTYECRASN DPKRNDLRQN PSITWIRAQA TISVLQKPRI VTSEEVIIRD SPVLPVTLQC NLTSSSHTLT YSYWTKNGVE LSATRKNASN MEYRINKPRA EDSGEYHCVY HFVSAPKANA TIEVKAAPDI TGHKRSENKN EGQDATMYCK SVGYPHPDWI WRKKENGMPM DIVNTSGRFF IINKENYTEL NIVNLQITED PGEYECNATN AIGSASVVTV LRVRSHLAPL WPFLGILAEI IILVVIIVVY EKRKRPDEVP DDDEPAGPMK TNSTNNHKDK NLRQRNTN