NPDC1_HUMAN » Neural proliferation differentiation and control protein 1

NPDC1_HUMAN » Neural proliferation differentiation and control protein 1
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Topology in Vesicle membrane
Topologyvesicle lumenal side
cytoplasmic side
NPDC1_HUMAN » Neural proliferation differentiation and control protein 1 » NPDC-1;
Hydrophobic Thickness 31.2 ± 3.0 Å
Tilt Angle 45 ± 0°
ΔGtransfer -20.6 kcal/mol
ΔGfold -19.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 181-206 (181-213)
Pathways none
PDB none
OPM none
Complexes none
Interactions

PLS1, Complex: NPDC1:PLS1, PubMed

Domains

AA: 1-325, Neural proliferation differentiation control-1 protein (NPDC1)

UniProt annotation for NPDC1_HUMAN » Neural proliferation differentiation and control protein 1
FUNCTION: Suppresses oncogenic transformation in neural and non- neural cells and down-regulates neural cell proliferation. Might be involved in transcriptional regulation (By similarity).

TISSUE SPECIFICITY: Strongly expressed in adult brain; especially in hippocampus, frontal lobe and temporal lobe.

UniProt features for NPDC1_HUMAN » Neural proliferation differentiation and control protein 1
SIGNAL 1 34 Potential.
CHAIN 35 325 Neural proliferation differentiation and control protein 1.
Amino Acid Sequence for NPDC1_HUMAN » Neural proliferation differentiation and control protein 1
MATPLPPPSP RHLRLLRLLL SGLVLGAALR GAAAGHPDVA ACPGSLDCAL KRRARCPPGA HACGPCLQPF QEDQQGLCVP RMRRPPGGGR PQPRLEDEID FLAQELARKE SGHSTPPLPK DRQRLPEPAT LGFSARGQGL ELGLPSTPGT PTPTPHTSLG SPVSSDPVHM SPLEPRGGQG DGLALVLILA FCVAGAAALS VASLCWCRLQ REIRLTQKAD YATAKAPGSP AAPRISPGDQ RLAQSAEMYH YQHQRQQMLC LERHKEPPKE LDTASSDEEN EDGDFTVYEC PGLAPTGEME VRNPLFDHAA LSAPLPAPSS PPALP