NOTC4_HUMAN » Neurogenic locus notch homolog protein 4

NOTC4_HUMAN » Neurogenic locus notch homolog protein 4
Magnify NOTC4_HUMAN » Neurogenic locus notch homolog protein 4Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
NOTC4_HUMAN » Neurogenic locus notch homolog protein 4 » Notch 4; hNotch4;
Hydrophobic Thickness 33.2 ± 4.0 Å
Tilt Angle 16 ± 7°
ΔGtransfer -22.4 kcal/mol
ΔGfold -16.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 1450-1474 (1448-1477)
Pathways

A third proteolytic cleavage releases NICD (Reactome)

Dorso-ventral axis formation (KEGG)

Gene Expression (Reactome)

NICD traffics to nucleus (Reactome)

Notch signaling pathway (KEGG)

Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor (Reactome)

Signal Transduction (Reactome)

PDB none
OPM none
Complexes none
Interactions

DLL4, Complex: DLL4:NOTC4, PubMed

Domains

AA: 35-57, PDBID: 2YGQ, Subunit A, Seq Identity:50%, Human growth factor-like EGF

AA: 127-149, PDBID: 2YGQ, Subunit A, Seq Identity:33%, Human growth factor-like EGF

AA: 160-189, PDBID: 1TOZ, Subunit A, Seq Identity:52%, EGF-like domain

AA: 194-238, PDBID: 1TOZ, Subunit A, Seq Identity:55%, Calcium-binding EGF domain

AA: 238-272, PDBID: 4XBM, Subunit B, Seq Identity:43%, EGF-like domain

AA: 280-308, PDBID: 1XKA, Subunit L, Seq Identity:51%, EGF-like domain

AA: 314-356, PDBID: 1TOZ, Subunit A, Seq Identity:47%, Calcium-binding EGF domain

AA: 364-385, PDBID: 2YGQ, Subunit A, Seq Identity:45%, Human growth factor-like EGF

AA: 432-474, PDBID: 4XL1, Subunit A, Seq Identity:67%, Calcium-binding EGF domain

AA: 479-509, PDBID: 1TOZ, Subunit A, Seq Identity:51%, EGF-like domain

AA: 517-547, PDBID: 1TOZ, Subunit A, Seq Identity:52%, EGF-like domain

AA: 551-590, PDBID: 1LMJ, Subunit A, Seq Identity:53%, Calcium-binding EGF domain

AA: 593-623, PDBID: 1TOZ, Subunit A, Seq Identity:57%, EGF-like domain

AA: 695-725, PDBID: 3H5C, Subunit B, Seq Identity:45%, EGF-like domain

AA: 771-801, PDBID: 4XBM, Subunit B, Seq Identity:48%, EGF-like domain

AA: 810-838, PDBID: 4XBM, Subunit B, Seq Identity:60%, EGF-like domain

AA: 845-886, PDBID: 4XL1, Subunit A, Seq Identity:41%, Calcium-binding EGF domain

AA: 896-926, PDBID: 4XBM, Subunit B, Seq Identity:46%, EGF-like domain

AA: 934-964, PDBID: 1TOZ, Subunit A, Seq Identity:52%, EGF-like domain

AA: 972-1002, PDBID: 4XBM, Subunit B, Seq Identity:48%, EGF-like domain

AA: 1050-1083, PDBID: 2VJ2, Subunit A, Seq Identity:47%, EGF-like domain

AA: 1167-1204, PDBID: 4ZLP, Subunit A, Seq Identity:50%, LNR domain

AA: 1211-1246, PDBID: 3ETO, Subunit A, Seq Identity:54%, LNR domain

AA: 1248-1285, PDBID: 3ETO, Subunit A, Seq Identity:65%, LNR domain

AA: 1295-1344, PDBID: 4ZLP, Subunit A, Seq Identity:33%, NOTCH protein

AA: 1378-1440, PDBID: 2OO4, Subunit A, Seq Identity:28%, NOTCH protein

AA: 1638-1731, PDBID: 1OT8, Subunit C, Seq Identity:34%, Ankyrin repeats (3 copies)

AA: 1705-1797, PDBID: 1YYH, Subunit B, Seq Identity:61%, Ankyrin repeats (3 copies)

UniProt annotation for NOTC4_HUMAN » Neurogenic locus notch homolog protein 4
FUNCTION: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity).

SUBUNIT: Heterodimer of a C-terminal fragment N(TM) and a N- terminal fragment N(EC) which are probably linked by disulfide bonds (By similarity). Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH4.

TISSUE SPECIFICITY: Highly expressed in the heart, moderately in the lung and placenta and at low levels in the liver, skeletal muscle, kidney, pancreas, spleen, lymph node, thymus, bone marrow and fetal liver. No expression was seen in adult brain or peripheral blood leukocytes.

UniProt features for NOTC4_HUMAN » Neurogenic locus notch homolog protein 4
SIGNAL 1 23 Potential.
CHAIN 24 2003 Neurogenic locus notch homolog protein 4.
CHAIN 1432 2003 Notch 4 extracellular truncation (By similarity).
CHAIN 1467 2003 Notch 4 intracellular domain (By similarity).
DOMAIN 24 63 EGF-like 1.
DOMAIN 64 115 EGF-like 2.
DOMAIN 118 155 EGF-like 3.
DOMAIN 156 192 EGF-like 4.
DOMAIN 194 232 EGF-like 5; calcium-binding (Potential).
DOMAIN 234 274 EGF-like 6.
DOMAIN 276 312 EGF-like 7; calcium-binding (Potential).
DOMAIN 314 353 EGF-like 8; calcium-binding (Potential).
DOMAIN 355 391 EGF-like 9; calcium-binding (Potential).
DOMAIN 392 430 EGF-like 10.
DOMAIN 432 473 EGF-like 11; calcium-binding (Potential).
DOMAIN 475 511 EGF-like 12; calcium-binding (Potential).
DOMAIN 513 549 EGF-like 13; calcium-binding (Potential).
DOMAIN 551 587 EGF-like 14; calcium-binding (Potential).
DOMAIN 589 625 EGF-like 15; calcium-binding (Potential).
DOMAIN 626 659 EGF-like 16.
DOMAIN 661 689 EGF-like 17.
DOMAIN 691 727 EGF-like 18.
DOMAIN 729 765 EGF-like 19.
DOMAIN 767 803 EGF-like 20.
DOMAIN 806 842 EGF-like 21.
DOMAIN 844 880 EGF-like 22.
DOMAIN 882 928 EGF-like 23.
DOMAIN 930 966 EGF-like 24.
DOMAIN 968 1004 EGF-like 25.
DOMAIN 1006 1044 EGF-like 26.
DOMAIN 1046 1085 EGF-like 27.
DOMAIN 1087 1126 EGF-like 28.
DOMAIN 1130 1171 EGF-like 29.
REPEAT 1170 1213 LNR 1.
REPEAT 1214 1250 LNR 2.
REPEAT 1251 1294 LNR 3.
REPEAT 1633 1665 ANK 1.
REPEAT 1666 1698 ANK 2.
REPEAT 1700 1732 ANK 3.
REPEAT 1733 1765 ANK 4.
REPEAT 1766 1798 ANK 5.
DISULFID 28 41 By similarity.
DISULFID 35 51 By similarity.
DISULFID 53 62 By similarity.
DISULFID 68 80 By similarity.
DISULFID 74 103 By similarity.
DISULFID 105 114 By similarity.
DISULFID 122 133 By similarity.
DISULFID 127 143 By similarity.
DISULFID 145 154 By similarity.
DISULFID 160 171 By similarity.
DISULFID 165 180 By similarity.
DISULFID 182 191 By similarity.
DISULFID 198 211 By similarity.
DISULFID 205 220 By similarity.
DISULFID 222 231 By similarity.
DISULFID 238 249 By similarity.
DISULFID 243 262 By similarity.
DISULFID 264 273 By similarity.
DISULFID 280 291 By similarity.
DISULFID 285 300 By similarity.
DISULFID 302 311 By similarity.
DISULFID 318 332 By similarity.
DISULFID 326 341 By similarity.
DISULFID 343 352 By similarity.
DISULFID 359 370 By similarity.
DISULFID 364 379 By similarity.
DISULFID 381 390 By similarity.
DISULFID 396 407 By similarity.
DISULFID 401 418 By similarity.
DISULFID 420 429 By similarity.
DISULFID 436 452 By similarity.
DISULFID 446 461 By similarity.
DISULFID 463 472 By similarity.
DISULFID 479 490 By similarity.
DISULFID 484 499 By similarity.
DISULFID 501 510 By similarity.
DISULFID 517 528 By similarity.
DISULFID 522 537 By similarity.
DISULFID 539 548 By similarity.
DISULFID 555 566 By similarity.
DISULFID 560 575 By similarity.
DISULFID 577 586 By similarity.
DISULFID 593 604 By similarity.
DISULFID 598 613 By similarity.
DISULFID 615 624 By similarity.
DISULFID 629 640 By similarity.
DISULFID 634 649 By similarity.
DISULFID 651 658 By similarity.
DISULFID 665 672 By similarity.
DISULFID 667 677 By similarity.
DISULFID 679 688 By similarity.
DISULFID 695 706 By similarity.
DISULFID 700 715 By similarity.
DISULFID 717 726 By similarity.
DISULFID 733 744 By similarity.
DISULFID 738 753 By similarity.
DISULFID 755 764 By similarity.
DISULFID 771 782 By similarity.
DISULFID 776 791 By similarity.
DISULFID 793 802 By similarity.
DISULFID 810 821 By similarity.
DISULFID 815 830 By similarity.
DISULFID 832 841 By similarity.
DISULFID 848 859 By similarity.
DISULFID 853 868 By similarity.
DISULFID 870 879 By similarity.
DISULFID 886 907 By similarity.
DISULFID 901 916 By similarity.
DISULFID 918 927 By similarity.
DISULFID 934 945 By similarity.
DISULFID 939 954 By similarity.
DISULFID 956 965 By similarity.
DISULFID 972 983 By similarity.
DISULFID 977 992 By similarity.
DISULFID 994 1003 By similarity.
DISULFID 1010 1023 By similarity.
DISULFID 1015 1032 By similarity.
DISULFID 1034 1043 By similarity.
DISULFID 1050 1061 By similarity.
DISULFID 1055 1073 By similarity.
DISULFID 1075 1084 By similarity.
DISULFID 1091 1102 By similarity.
DISULFID 1096 1114 By similarity.
DISULFID 1116 1125 By similarity.
DISULFID 1134 1146 By similarity.
DISULFID 1140 1159 By similarity.
DISULFID 1161 1170 By similarity.
DISULFID 1178 1191 By similarity.
DISULFID 1187 1203 By similarity.
DISULFID 1214 1238 By similarity.
DISULFID 1220 1233 By similarity.
DISULFID 1229 1245 By similarity.
DISULFID 1251 1277 By similarity.
DISULFID 1259 1272 By similarity.
DISULFID 1268 1284 By similarity.
Amino Acid Sequence for NOTC4_HUMAN » Neurogenic locus notch homolog protein 4
MQPPSLLLLL LLLLLLCVSV VRPRGLLCGS FPEPCANGGT CLSLSLGQGT CQCAPGFLGE TCQFPDPCQN AQLCQNGGSC QALLPAPLGL PSSPSPLTPS FLCTCLPGFT GERCQAKLED PCPPSFCSKR GRCHIQASGR PQCSCMPGWT GEQCQLRDFC SANPCVNGGV CLATYPQIQC HCPPGFEGHA CERDVNECFQ DPGPCPKGTS CHNTLGSFQC LCPVGQEGPR CELRAGPCPP RGCSNGGTCQ LMPEKDSTFH LCLCPPGFIG PDCEVNPDNC VSHQCQNGGT CQDGLDTYTC LCPETWTGWD CSEDVDECET QGPPHCRNGG TCQNSAGSFH CVCVSGWGGT SCEENLDDCI AATCAPGSTC IDRVGSFSCL CPPGRTGLLC HLEDMCLSQP CHGDAQCSTN PLTGSTLCLC QPGYSGPTCH QDLDECLMAQ QGPSPCEHGG SCLNTPGSFN CLCPPGYTGS RCEADHNECL SQPCHPGSTC LDLLATFHCL CPPGLEGQLC EVETNECASA PCLNHADCHD LLNGFQCICL PGFSGTRCEE DIDECRSSPC ANGGQCQDQP GAFHCKCLPG FEGPRCQTEV DECLSDPCPV GASCLDLPGA FFCLCPSGFT GQLCEVPLCA PNLCQPKQIC KDQKDKANCL CPDGSPGCAP PEDNCTCHHG HCQRSSCVCD VGWTGPECEA ELGGCISAPC AHGGTCYPQP SGYNCTCPTG YTGPTCSEEM TACHSGPCLN GGSCNPSPGG YYCTCPPSHT GPQCQTSTDY CVSAPCFNGG TCVNRPGTFS CLCAMGFQGP RCEGKLRPSC ADSPCRNRAT CQDSPQGPRC LCPTGYTGGS CQTLMDLCAQ KPCPRNSHCL QTGPSFHCLC LQGWTGPLCN LPLSSCQKAA LSQGIDVSSL CHNGGLCVDS GPSYFCHCPP GFQGSLCQDH VNPCESRPCQ NGATCMAQPS GYLCQCAPGY DGQNCSKELD ACQSQPCHNH GTCTPKPGGF HCACPPGFVG LRCEGDVDEC LDQPCHPTGT AACHSLANAF YCQCLPGHTG QWCEVEIDPC HSQPCFHGGT CEATAGSPLG FICHCPKGFE GPTCSHRAPS CGFHHCHHGG LCLPSPKPGF PPRCACLSGY GGPDCLTPPA PKGCGPPSPC LYNGSCSETT GLGGPGFRCS CPHSSPGPRC QKPGAKGCEG RSGDGACDAG CSGPGGNWDG GDCSLGVPDP WKGCPSHSRC WLLFRDGQCH PQCDSEECLF DGYDCETPPA CTPAYDQYCH DHFHNGHCEK GCNTAECGWD GGDCRPEDGD PEWGPSLALL VVLSPPALDQ QLFALARVLS LTLRVGLWVR KDRDGRDMVY PYPGARAEEK LGGTRDPTYQ ERAAPQTQPL GKETDSLSAG FVVVMGVDLS RCGPDHPASR CPWDPGLLLR FLAAMAAVGA LEPLLPGPLL AVHPHAGTAP PANQLPWPVL CSPVAGVILL ALGALLVLQL IRRRRREHGA LWLPPGFTRR PRTQSAPHRR RPPLGEDSIG LKALKPKAEV DEDGVVMCSG PEEGEEVGQA EETGPPSTCQ LWSLSGGCGA LPQAAMLTPP QESEMEAPDL DTRGPDGVTP LMSAVCCGEV QSGTFQGAWL GCPEPWEPLL DGGACPQAHT VGTGETPLHL AARFSRPTAA RRLLEAGANP NQPDRAGRTP LHAAVAADAR EVCQLLLRSR QTAVDARTED GTTPLMLAAR LAVEDLVEEL IAAQADVGAR DKWGKTALHW AAAVNNARAA RSLLQAGADK DAQDNREQTP LFLAAREGAV EVAQLLLGLG AARELRDQAG LAPADVAHQR NHWDLLTLLE GAGPPEARHK ATPGREAGPF PRARTVSVSV PPHGGGALPR CRTLSAGAGP RGGGACLQAR TWSVDLAARG GGAYSHCRSL SGVGAGGGPT PRGRRFSAGM RGPRPNPAIM RGRYGVAAGR GGRVSTDDWP CDWVALGACG SASNIPIPPP CLTPSPERGS PQLDCGPPAL QEMPINQGGE GKK