NOMO3_HUMAN » Nodal modulator 3

NOMO3_HUMAN » Nodal modulator 3
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
NOMO3_HUMAN » Nodal modulator 3 » pM5 protein 3;
Hydrophobic Thickness 29.8 ± 2.7 Å
Tilt Angle 6 ± 6°
ΔGtransfer -13.7 kcal/mol
ΔGfold -8.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 1156-1176 (1152-1178)
Pathways none
PDB none
OPM none
Complexes none
Interactions

NCLN, Complex: NCLN:NOMO3, PubMed

RYK, Complex: NOMO3:RYK, PubMed

Domains

AA: 330-406, PDBID: 2NSM, Subunit A, Seq Identity:28%, Carboxypeptidase regulatory-like domain

UniProt annotation for NOMO3_HUMAN » Nodal modulator 3
FUNCTION: May antagonize Nodal signaling.
UniProt features for NOMO3_HUMAN » Nodal modulator 3
SIGNAL 1 31 Potential.
CHAIN 32 1222 Nodal modulator 3.
Amino Acid Sequence for NOMO3_HUMAN » Nodal modulator 3
MLVGQGAGPL GPAVVTAAVV LLLSGVGPAH GSEDIVVGCG GFVKSDVEIN YSLIEIKLYT KHGTLKYQTD CAPNNGYFMI PLYDKGDFIL KIEPPLGWSF EPTTVELHVD GVSDICTKGG DINFVFTGFS VNGKVLSKGQ PLGPAGVQVS LRNTGTEAKI QSTVTQPGGK FAFFKVLPGD YEILATHPTW ALKEASTTVR VTNSNANAAS PLIVAGYNVS GSVRSDGEPM KGVKFLLFSS LVTKEDVLGC NVSPVPGFQP QDESLVYLCY TVSREDGSFS FYSLPSGGYT VIPFYRGERI TFDVAPSRLD FTVEHDSLKI EPVFHVMGFS VTGRVLNGPE GDGVPEAVVT LNNQIKVKTK ADGSFRLENI TTGTYTIHAQ KEHLYFETVT IKIAPNTPQL ADIVATGFSV CGQISIIRFP DTVKQMNKYK VVLSSQDKDK SLVTVETDAH GSFCFKANPG TYKVQVMVPE AETRAGLTLK PQTFPLTVTD RPVMDVAFVQ FLASVSGKVS CLDTCGDLLV TLQSLSRQGE KRSLQLSGKV NAMTFTFDNV LPGKYKISIM HEDWCWKNKS LEVEVLEDDV SAVEFRQTGY MLRCSLSHAI TLEFYQDGNG RENVGIYNLS KGVNRFCLSK PGVYKVTPRS CHRFEQAFYT YDTSSPSILT LTAIRHHVLG TITTDKMMDV TVTIKSSIDS EPALVLGPLK SVQELRREQQ LAEIEARRQE REKNGKEEGE ERMTKPPVQE MVDELQGPFS YDFSYWARSG EKITVTPSSK ELLFYPPSME AVVSGESCPG KLIEIHGKAG LFLEGQIHPE LEGVEIVISE KGASSPLITV FTDDKGAYSV GPLHSDLEYT VTSQKEGYVL TAVEGTIGDF KAYALAGVSF EIKAEDDQPL PGVLLSLSGG LFRSNLLTQD NGILTFSNLS PGQYYFKPMM KEFRFEPSSQ MIEVQEGQNL KITITGYRTA YSCYGTVSSL NGEPEQGVAM EAVGQNDCSI YGEDTVTDEE GKFRLRGLLP GCVYHVQLKA EGNDHIERAL PHHRVIEVGN NDIDDVNIIV FRQINQFDLS GNVITSSEYL PTLWVKLYKS ENLDNPIQTV SLGQSLFFHF PPLLRDGENY VVLLDSTLPR SQYDYILPQV SFTAVGYHKH FTLIFNPTRK LPEQDIAQGS YIALPLTLLV LLAGYNHDKL IPLLLQLTSR LQGVGALGQA ASDNSGPEDA KRQAKKQKTR RT