NLGNY_HUMAN » Neuroligin-4, Y-linked

NLGNY_HUMAN » Neuroligin-4, Y-linked
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
NLGNY_HUMAN » Neuroligin-4, Y-linked » Neuroligin Y;
Hydrophobic Thickness 32.0 ± 2.0 Å
Tilt Angle 0 ± 0°
ΔGtransfer -32.9 kcal/mol
ΔGfold -19.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 675-700 (671-704)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 44-590, PDBID: 2WQZ, Subunit A, Seq Identity:92%, Carboxylesterase family

UniProt annotation for NLGNY_HUMAN » Neuroligin-4, Y-linked
FUNCTION: Putative neuronal cell surface protein involved in cell- cell-interactions.

SUBUNIT: Homodimer. Interacts with NRXN1 in a calcium-dependent manner. Interacts through its C-terminus with DLG4/PSD-95 third PDZ domain (By similarity).

TISSUE SPECIFICITY: Expressed in fetal and adult brain, prostate and testis.

UniProt features for NLGNY_HUMAN » Neuroligin-4, Y-linked
SIGNAL 1 43 Potential.
CHAIN 44 816 Neuroligin-4, Y-linked.
REGION 359 364 Interaction with NRXN1 (By similarity).
DISULFID 110 146 By similarity.
DISULFID 306 317 By similarity.
DISULFID 476 510 By similarity.
Amino Acid Sequence for NLGNY_HUMAN » Neuroligin-4, Y-linked
MLRPQGLLWL PLLFTSVCVM LNSNVLLWIT ALAIKFTLID SQAQYPVVNT NYGKIQGLRT PLPSEILGPV EQYLGVPYAS PPTGERRFQP PESPSSWTGI RNATQFSAVC PQHLDERFLL HDMLPIWFTT SLDTLMTYVQ DQNEDCLYLN IYVPMEDDIH EQNSKKPVMV YIHGGSYMEG TGNMIDGSIL ASYGNVIVIT INYRLGILGF LSTGDQAAKG NYGLLDQIQA LRWIEENVGA FGGDPKRVTI FGSGAGASCV SLLTLSHYSE GLFQKAIIQS GTALSSWAVN YQPAKYTRIL ADKVGCNMLD TTDMVECLKN KNYKELIQQT ITPATYHIAF GPVIDGDVIP DDPQILMEQG EFLNYDIMLG VNQGEGLKFV DGIVDNEDGV TPNDFDFSVS NFVDNLYGYP EGKDTLRETI KFMYTDWADK ENPETRRKTL VALFTDHQWV APAVATADLH AQYGSPTYFY AFYHHCQSEM KPSWADSAHG DEVPYVFGIP MIGPTELFSC NFSKNDVMLS AVVMTYWTNF AKTGDPNQPV PQDTKFIHTK PNRFEEVAWS KYNPKDQLYL HIGLKPRVRD HYRATKVAFW LELVPHLHNL NEIFQYVSTT TKVPPPDMTS FPYGTRRSPA KIWPTTKRPA ITPANNPKHS KDPHKTGPED TTVLIETKRD YSTELSVTIA VGASLLFLNI LAFAALYYKK DKRRHETHRH PSPQRNTTND ITHIQNEEIM SLQMKQLEHD HECESLQAHD TLRLTCPPDY TLTLRRSPDD IPFMTPNTIT MIPNTLMGMQ PLHTFKTFSG GQNSTNLPHG HSTTRV