NLGNX_HUMAN » Neuroligin-4, X-linked

NLGNX_HUMAN » Neuroligin-4, X-linked
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
NLGNX_HUMAN » Neuroligin-4, X-linked » Neuroligin X; HNLX;
Hydrophobic Thickness 32.0 ± 2.0 Å
Tilt Angle 0 ± 0°
ΔGtransfer -32.9 kcal/mol
ΔGfold -19.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 675-700 (671-704)
Pathways

Cell adhesion molecules (KEGG)

PDB 2wqz (A/B=43-619), 2xb6 (A/B=44-619), 3be8 (A/B=44-619)
OPM 2xb6
Complexes

NLGNX:NLGNX_HUMAN

Interactions

NLGNX, Complex: Homodimer of neuroligin-4, PDBID: 3BE8

NRX1B, Complex: NLGNX:NRX1B, PDBID: 2wqz

Domains

AA: 44-590, PDBID: 2WQZ, Subunit A, Seq Identity:100%, Carboxylesterase family

UniProt annotation for NLGNX_HUMAN » Neuroligin-4, X-linked
FUNCTION: Putative neuronal cell surface protein involved in cell- cell-interactions.

SUBUNIT: Homodimer. Interacts with NRXN1 in a calcium-dependent manner. Interacts through its C-terminus with DLG4/PSD-95 third PDZ domain.

TISSUE SPECIFICITY: Expressed at highest levels in heart. Expressed at lower levels in liver, skeletal muscle and pancreas and at very low levels in brain.

DISEASE: Autism, X-linked 2 (AUTSX2) OMIM: A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

DISEASE: Asperger syndrome, X-linked, 2 (ASPGX2) OMIM: A syndrome with features similar to autism. Affected individuals exhibit qualitative impairment in social interaction, as manifest by impairment in the use of non-verbal behaviors such as eye-to- eye gaze, facial expression, body postures, and gestures, failure to develop appropriate peer relationships, and lack of social sharing or reciprocity. Patients also exhibit restricted, repetitive and stereotyped patterns of behavior, interests, and activities, including abnormal preoccupation with certain activities and inflexible adherence to routines or rituals. Asperger syndrome is primarily distinguished from autism by the higher cognitive abilities and a more normal and timely development of language and communicative phrases. associated with variations affecting the gene represented in this entry.

UniProt features for NLGNX_HUMAN » Neuroligin-4, X-linked
SIGNAL 1 41
CHAIN 42 816 Neuroligin-4, X-linked.
REGION 359 364 Interaction with NRXN1.
DISULFID 110 146
DISULFID 306 317
DISULFID 476 510
Amino Acid Sequence for NLGNX_HUMAN » Neuroligin-4, X-linked
MSRPQGLLWL PLLFTPVCVM LNSNVLLWLT ALAIKFTLID SQAQYPVVNT NYGKIRGLRT PLPNEILGPV EQYLGVPYAS PPTGERRFQP PEPPSSWTGI RNTTQFAAVC PQHLDERSLL HDMLPIWFTA NLDTLMTYVQ DQNEDCLYLN IYVPTEDDIH DQNSKKPVMV YIHGGSYMEG TGNMIDGSIL ASYGNVIVIT INYRLGILGF LSTGDQAAKG NYGLLDQIQA LRWIEENVGA FGGDPKRVTI FGSGAGASCV SLLTLSHYSE GLFQKAIIQS GTALSSWAVN YQPAKYTRIL ADKVGCNMLD TTDMVECLRN KNYKELIQQT ITPATYHIAF GPVIDGDVIP DDPQILMEQG EFLNYDIMLG VNQGEGLKFV DGIVDNEDGV TPNDFDFSVS NFVDNLYGYP EGKDTLRETI KFMYTDWADK ENPETRRKTL VALFTDHQWV APAVATADLH AQYGSPTYFY AFYHHCQSEM KPSWADSAHG DEVPYVFGIP MIGPTELFSC NFSKNDVMLS AVVMTYWTNF AKTGDPNQPV PQDTKFIHTK PNRFEEVAWS KYNPKDQLYL HIGLKPRVRD HYRATKVAFW LELVPHLHNL NEIFQYVSTT TKVPPPDMTS FPYGTRRSPA KIWPTTKRPA ITPANNPKHS KDPHKTGPED TTVLIETKRD YSTELSVTIA VGASLLFLNI LAFAALYYKK DKRRHETHRR PSPQRNTTND IAHIQNEEIM SLQMKQLEHD HECESLQAHD TLRLTCPPDY TLTLRRSPDD IPLMTPNTIT MIPNTLTGMQ PLHTFNTFSG GQNSTNLPHG HSTTRV