NLGN2_HUMAN » Neuroligin-2

NLGN2_HUMAN » Neuroligin-2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
NLGN2_HUMAN » Neuroligin-2 »
Hydrophobic Thickness 32.4 ± 1.6 Å
Tilt Angle 0 ± 1°
ΔGtransfer -33.0 kcal/mol
ΔGfold -18.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 676-700 (672-703)
Pathways

Cell adhesion molecules (KEGG)

PDB none
OPM 3bl8 (MOUSE)
Complexes

NLGN2:NLGN2_MOUSE

Interactions

NLGN2, Complex: Homodimer of neuroligin-2, PDBID: 3BL8

NRX1A, Complex: NRX1A.NRX1B:NLGN2, PubMed

NRX2A, Complex: NRX2A.NRX2B:NLGN2, PubMed

NRX3A, Complex: NLGN2:NRX3A.NRX3B, PubMed

Domains

AA: 40-601, PDBID: 3BL8, Subunit A, Seq Identity:100%, Carboxylesterase family

UniProt annotation for NLGN2_HUMAN » Neuroligin-2
FUNCTION: Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma- aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity).

SUBUNIT: Interacts with NRXN1, NRXN2 and NRXN3. Interacts (via its C-terminus) with DLG4/PSD-95 (via PDZ domain 3). Interacts with INADL. Interacts with GPHN (By similarity). Interacts with MDGA1 and MDGA2 (By similarity).

TISSUE SPECIFICITY: Expressed in the blood vessel walls. Detected in colon, brain and pancreas islets of Langerhans (at protein level). Detected in brain, and at lower levels in pancreas islet beta cells.

UniProt features for NLGN2_HUMAN » Neuroligin-2
SIGNAL 1 14 Potential.
CHAIN 15 835 Neuroligin-2.
DISULFID 106 141 By similarity.
DISULFID 317 328 By similarity.
DISULFID 487 521 By similarity.
Amino Acid Sequence for NLGN2_HUMAN » Neuroligin-2
MWLLALCLVG LAGAQRGGGG PGGGAPGGPG LGLGSLGEER FPVVNTAYGR VRGVRRELNN EILGPVVQFL GVPYATPPLG ARRFQPPEAP ASWPGVRNAT TLPPACPQNL HGALPAIMLP VWFTDNLEAA ATYVQNQSED CLYLNLYVPT EDGPLTKKRD EATLNPPDTD IRDPGKKPVM LFLHGGSYME GTGNMFDGSV LAAYGNVIVA TLNYRLGVLG FLSTGDQAAK GNYGLLDQIQ ALRWLSENIA HFGGDPERIT IFGSGAGASC VNLLILSHHS EGLFQKAIAQ SGTAISSWSV NYQPLKYTRL LAAKVGCDRE DSAEAVECLR RKPSRELVDQ DVQPARYHIA FGPVVDGDVV PDDPEILMQQ GEFLNYDMLI GVNQGEGLKF VEDSAESEDG VSASAFDFTV SNFVDNLYGY PEGKDVLRET IKFMYTDWAD RDNGEMRRKT LLALFTDHQW VAPAVATAKL HADYQSPVYF YTFYHHCQAE GRPEWADAAH GDELPYVFGV PMVGATDLFP CNFSKNDVML SAVVMTYWTN FAKTGDPNQP VPQDTKFIHT KPNRFEEVVW SKFNSKEKQY LHIGLKPRVR DNYRANKVAF WLELVPHLHN LHTELFTTTT RLPPYATRWP PRPPAGAPGT RRPPPPATLP PEPEPEPGPR AYDRFPGDSR DYSTELSVTV AVGASLLFLN ILAFAALYYK RDRRQELRCR RLSPPGGSGS GVPGGGPLLP AAGRELPPEE ELVSLQLKRG GGVGADPAEA LRPACPPDYT LALRRAPDDV PLLAPGALTL LPSGLGPPPP PPPPSLHPFG PFPPPPPTAT SHNNTLPHPH STTRV