NKG2E_HUMAN » NKG2-E type II integral membrane protein

NKG2E_HUMAN » NKG2-E type II integral membrane protein
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
NKG2E_HUMAN » NKG2-E type II integral membrane protein » NK cell receptor E;NKG2-E-activating NK receptor;
Hydrophobic Thickness 34.4 ± 3.8 Å
Tilt Angle 25 ± 11°
ΔGtransfer -23.6 kcal/mol
ΔGfold -11.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 73- 98 (73-102)
Pathways

Antigen processing and presentation (KEGG)

Natural killer cell mediated cytotoxicity (KEGG)

PDB none
OPM none
Complexes none
Interactions

KLRD1, Complex: KLRD1:NKG2E, PubMed

TYOBP, Complex: TYOBP:NKG2E, PubMed

Domains

AA: 134-225, PDBID: 3BDW, Subunit D, Seq Identity:70%, Lectin C-type domain

UniProt annotation for NKG2E_HUMAN » NKG2-E type II integral membrane protein
FUNCTION: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.

SUBUNIT: Can form disulfide-bonded heterodimer with CD94.

TISSUE SPECIFICITY: Natural killer cells.

UniProt features for NKG2E_HUMAN » NKG2-E type II integral membrane protein
CHAIN 1 240 NKG2-E type II integral membrane protein.
DOMAIN 116 230 C-type lectin.
DISULFID 117 128 By similarity.
DISULFID 207 220 By similarity.
Amino Acid Sequence for NKG2E_HUMAN » NKG2-E type II integral membrane protein
MNKQRGTFSE VSLAQDPKPQ QRKPKGNKSS ISGTEQEIFQ VELNLQNASL NHQGIDKIYD CQGLLPPPEK LTAEVLGIIC IVLMATVLKT IVLIPFLEQN NSSPNTRTQK ARPCGHCPEE WITYSNSCYY IGKERRTWEE SLQACASKNS SSLLSIDNEE EMKFLASILP SSWIGVFRNS SHHPWVTING LAFKHEIKDS DHAERNCAML HVRGLISDQC GSSRIIRRGF IMLTRLVLNS