NKG2C_HUMAN » NKG2-C type II integral membrane protein

NKG2C_HUMAN » NKG2-C type II integral membrane protein
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
NKG2C_HUMAN » NKG2-C type II integral membrane protein » CD159 antigen-like family member C;NK cell receptor C;NKG2-C-activating NK receptor;
Hydrophobic Thickness 34.4 ± 3.8 Å
Tilt Angle 25 ± 11°
ΔGtransfer -23.6 kcal/mol
ΔGfold -11.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 73- 98 (73-102)
Pathways

Antigen processing and presentation (KEGG)

Immune System (Reactome)

Natural killer cell mediated cytotoxicity (KEGG)

PDB 2l35 (A=72-100)
OPM 2l35
Complexes

TYOBP:NKG2C_HUMAN

Interactions

HLAE, Complex: HLAE:NKG2C, PubMed

KLRD1, Complex: NKG2C:KLRD1, PubMed

TYOBP, Complex: NKG2C:TYOBP, PDBID: 2l35, PubMed

Domains

AA: 134-229, PDBID: 3BDW, Subunit D, Seq Identity:93%, Lectin C-type domain

UniProt annotation for NKG2C_HUMAN » NKG2-C type II integral membrane protein
FUNCTION: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.

SUBUNIT: Can form disulfide-bonded heterodimer with CD94. Interacts with TYROBP.

TISSUE SPECIFICITY: Natural killer cells.

UniProt features for NKG2C_HUMAN » NKG2-C type II integral membrane protein
CHAIN 1 231 NKG2-C type II integral membrane protein.
DOMAIN 116 229 C-type lectin.
DISULFID 117 128 By similarity.
DISULFID 145 227 By similarity.
DISULFID 206 219 By similarity.
Amino Acid Sequence for NKG2C_HUMAN » NKG2-C type II integral membrane protein
MSKQRGTFSE VSLAQDPKRQ QRKPKGNKSS ISGTEQEIFQ VELNLQNPSL NHQGIDKIYD CQGLLPPPEK LTAEVLGIIC IVLMATVLKT IVLIPFLEQN NSSPNTRTQK ARHCGHCPEE WITYSNSCYY IGKERRTWEE SLLACTSKNS SLLSIDNEEE MKFLASILPS SWIGVFRNSS HHPWVTINGL AFKHKIKDSD NAELNCAVLQ VNRLKSAQCG SSMIYHCKHK L