NKG2A_HUMAN » NKG2-A/NKG2-B type II integral membrane protein

NKG2A_HUMAN » NKG2-A/NKG2-B type II integral membrane protein
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
NKG2A_HUMAN » NKG2-A/NKG2-B type II integral membrane protein » CD159 antigen-like family member A;NK cell receptor A;NKG2-A/B-activating NK receptor;
Hydrophobic Thickness 34.4 ± 5.2 Å
Tilt Angle 24 ± 7°
ΔGtransfer -27.3 kcal/mol
ΔGfold -19.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 67- 92 (67-101)
Pathways

Antigen processing and presentation (KEGG)

Graft-versus-host disease (KEGG)

Immune System (Reactome)

Natural killer cell mediated cytotoxicity (KEGG)

PDB 3bdw (B/D=113-232), 2rmx (B=1-15), 2yu7 (B=33-47), 3cdg (F/K=113-232), 3cii (H/J=113-232)
OPM none
Complexes

HLAE:NKG2A:KLRD1:HLAG:B2MG_HUMAN

NKG2A:KLRD1_HUMAN

Interactions

HLAE, Complex: B2MG:HLAE:HLAG:KLRD1:NKG2A, PDBID: 3cdg

HLAG, Complex: B2MG:HLAE:HLAG:KLRD1:NKG2A, PDBID: 3cdg

KLRD1, Complex: B2MG:HLAE:HLAG:KLRD1:NKG2A, PDBID: 3cdg

Domains

AA: 136-231, PDBID: 3BDW, Subunit D, Seq Identity:100%, Lectin C-type domain

UniProt annotation for NKG2A_HUMAN » NKG2-A/NKG2-B type II integral membrane protein
FUNCTION: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.

SUBUNIT: Can form disulfide-bonded heterodimer with CD94.

TISSUE SPECIFICITY: Natural killer cells.

UniProt features for NKG2A_HUMAN » NKG2-A/NKG2-B type II integral membrane protein
CHAIN 1 233 NKG2-A/NKG2-B type II integral membrane protein.
DOMAIN 118 231 C-type lectin.
DISULFID 116 116 Interchain (with C-59 in KLRD1).
DISULFID 119 130
DISULFID 147 229
DISULFID 208 221
Amino Acid Sequence for NKG2A_HUMAN » NKG2-A/NKG2-B type II integral membrane protein
MDNQGVIYSD LNLPPNPKRQ QRKPKGNKSS ILATEQEITY AELNLQKASQ DFQGNDKTYH CKDLPSAPEK LIVGILGIIC LILMASVVTI VVIPSTLIQR HNNSSLNTRT QKARHCGHCP EEWITYSNSC YYIGKERRTW EESLLACTSK NSSLLSIDNE EEMKFLSIIS PSSWIGVFRN SSHHPWVTMN GLAFKHEIKD SDNAELNCAV LQVNRLKSAQ CGSSIIYHCK HKL