NFASC_HUMAN » Neurofascin

NFASC_HUMAN » Neurofascin
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
NFASC_HUMAN » Neurofascin »
Hydrophobic Thickness 33.2 ± 4.6 Å
Tilt Angle 3 ± 0°
ΔGtransfer -46.3 kcal/mol
ΔGfold -26.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 1214-1239 (1209-1242)
Pathways

Cell adhesion molecules (KEGG)

Developmental Biology (Reactome)

PDB 3p3y (A=25-428), 3p40 (A=25-428)
OPM none
Complexes none
Interactions

CNTP1, Complex: NFASC:CNTP1, PubMed

NRCAM, Complex: NRCAM:NFASC, PubMed

SCN1B, Complex: NFASC:SCN1B, PubMed

SCN3B, Complex: NFASC:SCN3B, PubMed

Domains

AA: 40-122, PDBID: 3P3Y, Subunit A, Seq Identity:100%, Immunoglobulin domain

AA: 146-222, PDBID: 3P3Y, Subunit A, Seq Identity:100%, Immunoglobulin domain

AA: 243-320, PDBID: 3P3Y, Subunit A, Seq Identity:100%, Immunoglobulin domain

AA: 338-412, PDBID: 3P3Y, Subunit A, Seq Identity:100%, Immunoglobulin domain

AA: 434-518, PDBID: 1DJS, Subunit A, Seq Identity:36%, Immunoglobulin I-set domain

AA: 522-609, PDBID: 2V9Q, Subunit A, Seq Identity:33%, Immunoglobulin I-set domain

AA: 629-714, PDBID: 1UEY, Subunit A, Seq Identity:47%, Fibronectin type III domain

AA: 729-813, PDBID: 1UEY, Subunit A, Seq Identity:40%, Fibronectin type III domain

AA: 827-920, PDBID: 1UEN, Subunit A, Seq Identity:38%, Fibronectin type III domain

AA: 933-1018, PDBID: 1X5L, Subunit A, Seq Identity:30%, Fibronectin type III domain

AA: 1118-1195, PDBID: 2N1K, Subunit A, Seq Identity:27%, Fibronectin type III domain

AA: 1239-1323, Bravo-like intracellular region

UniProt annotation for NFASC_HUMAN » Neurofascin
FUNCTION: Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions.

SUBUNIT: Horseshoe-shaped homodimer. Probable constituent of a neurofascin/NRCAM/ankyrin-G complex. Associates with the sodium channel beta-1 (SCN1B) and beta-3 (SCN3B) subunits. Interacts with GLDN/gliomedin (By similarity). Interacts with MYOC.

DOMAIN: Homophilic adhesion is primarily mediated by the interaction of the second Ig-like domains.

UniProt features for NFASC_HUMAN » Neurofascin
SIGNAL 1 24 Potential.
CHAIN 25 1347 Neurofascin.
DOMAIN 41 137 Ig-like C2-type 1.
DOMAIN 143 230 Ig-like C2-type 2.
DOMAIN 244 332 Ig-like C2-type 3.
DOMAIN 337 424 Ig-like C2-type 4.
DOMAIN 429 517 Ig-like C2-type 5.
DOMAIN 521 603 Ig-like C2-type 6.
DOMAIN 628 720 Fibronectin type-III 1.
DOMAIN 727 820 Fibronectin type-III 2.
DOMAIN 825 927 Fibronectin type-III 3.
DOMAIN 932 1025 Fibronectin type-III 4.
DOMAIN 1115 1201 Fibronectin type-III 5.
DISULFID 63 118
DISULFID 162 213
DISULFID 268 316
DISULFID 358 408
DISULFID 452 501 Potential.
DISULFID 543 592 Potential.
Amino Acid Sequence for NFASC_HUMAN » Neurofascin
MARQPPPPWV HAAFLLCLLS LGGAIEIPMD PSIQNELTQP PTITKQSAKD HIVDPRDNIL IECEAKGNPA PSFHWTRNSR FFNIAKDPRV SMRRRSGTLV IDFRSGGRPE EYEGEYQCFA RNKFGTALSN RIRLQVSKSP LWPKENLDPV VVQEGAPLTL QCNPPPGLPS PVIFWMSSSM EPITQDKRVS QGHNGDLYFS NVMLQDMQTD YSCNARFHFT HTIQQKNPFT LKVLTTRGVA ERTPSFMYPQ GTASSQMVLR GMDLLLECIA SGVPTPDIAW YKKGGDLPSD KAKFENFNKA LRITNVSEED SGEYFCLASN KMGSIRHTIS VRVKAAPYWL DEPKNLILAP GEDGRLVCRA NGNPKPTVQW MVNGEPLQSA PPNPNREVAG DTIIFRDTQI SSRAVYQCNT SNEHGYLLAN AFVSVLDVPP RMLSPRNQLI RVILYNRTRL DCPFFGSPIP TLRWFKNGQG SNLDGGNYHV YENGSLEIKM IRKEDQGIYT CVATNILGKA ENQVRLEVKD PTRIYRMPED QVARRGTTVQ LECRVKHDPS LKLTVSWLKD DEPLYIGNRM KKEDDSLTIF GVAERDQGSY TCVASTELDQ DLAKAYLTVL ADQATPTNRL AALPKGRPDR PRDLELTDLA ERSVRLTWIP GDANNSPITD YVVQFEEDQF QPGVWHDHSK YPGSVNSAVL RLSPYVNYQF RVIAINEVGS SHPSLPSERY RTSGAPPESN PGDVKGEGTR KNNMEITWTP MNATSAFGPN LRYIVKWRRR ETREAWNNVT VWGSRYVVGQ TPVYVPYEIR VQAENDFGKG PEPESVIGYS GEDYPRAAPT EVKVRVMNST AISLQWNRVY SDTVQGQLRE YRAYYWRESS LLKNLWVSQK RQQASFPGDR LRGVVSRLFP YSNYKLEMVV VNGRGDGPRS ETKEFTTPEG VPSAPRRFRV RQPNLETINL EWDHPEHPNG IMIGYTLKYV AFNGTKVGKQ IVENFSPNQT KFTVQRTDPV SRYRFTLSAR TQVGSGEAVT EESPAPPNEA TPTAAPPTLP PTTVGATGAV SSTDATAIAA TTEATTVPII PTVAPTTIAT TTTVATTTTT TAAATTTTES PPTTTSGTKI HESAPDEQSI WNVTVLPNSK WANITWKHNF GPGTDFVVEY IDSNHTKKTV PVKAQAQPIQ LTDLYPGMTY TLRVYSRDNE GISSTVITFM TSTAYTNNQA DIATQGWFIG LMCAIALLVL ILLIVCFIKR SRGGKYPVRE KKDVPLGPED PKEEDGSFDY SDEDNKPLQG SQTSLDGTIK QQESDDSLVD YGEGGEGQFN EDGSFIGQYT VKKDKEETEG NESSEATSPV NAIYSLA