NFAM1_HUMAN » NFAT activation molecule 1

NFAM1_HUMAN » NFAT activation molecule 1
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Topology in Plasma membrane
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cytoplasmic side
NFAM1_HUMAN » NFAT activation molecule 1 » Calcineurin/NFAT-activating ITAM-containing protein;NFAT-activating protein with ITAM motif 1;
Hydrophobic Thickness 36.4 ± 2.4 Å
Tilt Angle 0 ± 2°
ΔGtransfer -49.8 kcal/mol
ΔGfold -15.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 161-189 (161-191)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains none
UniProt annotation for NFAM1_HUMAN » NFAT activation molecule 1
FUNCTION: May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross- linking.

SUBUNIT: No direct interaction with the B-cell antigen receptor (BCR). Interacts with SYK; probably involved in BCR signaling. Interacts with ZAP70 (By similarity).

TISSUE SPECIFICITY: Highly expressed in neutrophils, primary monocytes, mast cells, monocytic cell lines and lymphocytes. Also expressed in spleen B and T-cells, and lung. Expressed at low level in non-immune tissue.

DOMAIN: The ITAM domain displays no close similarity to any existing ITAMs, except for four conserved positions. The phosphorylated ITAM domain binds ZAP70 and SYK.

UniProt features for NFAM1_HUMAN » NFAT activation molecule 1
SIGNAL 1 42 Potential.
CHAIN 43 270 NFAT activation molecule 1.
DOMAIN 50 150 Ig-like V-type.
DOMAIN 209 237 ITAM.
DISULFID 65 114 By similarity.
Amino Acid Sequence for NFAM1_HUMAN » NFAT activation molecule 1
MENQPVRWRA LPGLPRPPGL PAAPWLLLGV LLLPGTLRLA GGQSVTHTGL PIMASLANTA ISFSCRITYP YTPQFKVFTV SYFHEDLQGQ RSPKKPTNCH PGLGTENQSH TLDCQVTLVL PGASATGTYY CSVHWPHSTV RGSGTFILVR DAGYREPPQS PQKLLLFGFT GLLSVLSVVG TALLLWNKKR MRGPGKDPTR KCPDPRSASS PKQHPSESVY TALQRRETEV YACIENEDGS SPTAKQSPLS QERPHRFEDD GELNLVYENL