NETO2_HUMAN » Neuropilin and tolloid-like protein 2

NETO2_HUMAN » Neuropilin and tolloid-like protein 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
NETO2_HUMAN » Neuropilin and tolloid-like protein 2 » Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2;
Hydrophobic Thickness 33.2 ± 2.8 Å
Tilt Angle 2 ± 1°
ΔGtransfer -38.5 kcal/mol
ΔGfold -15.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 339-371 (339-372)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 45-156, PDBID: 3KQ4, Subunit B, Seq Identity:36%, CUB domain

AA: 177-289, PDBID: 1NT0, Subunit A, Seq Identity:23%, CUB domain

AA: 295-331, PDBID: 2I1P, Subunit A, Seq Identity:42%, Low-density lipoprotein receptor domain class A

UniProt annotation for NETO2_HUMAN » Neuropilin and tolloid-like protein 2
FUNCTION: Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission (By similarity).

SUBUNIT: Interacts with GRIK2 and GRIK3, but neither with AMPA-nor with NMDA-sensitive glutamate receptors.

UniProt features for NETO2_HUMAN » Neuropilin and tolloid-like protein 2
SIGNAL 1 22
CHAIN 23 525 Neuropilin and tolloid-like protein 2.
DOMAIN 45 159 CUB 1.
DOMAIN 177 292 CUB 2.
DOMAIN 296 332 LDL-receptor class A.
DISULFID 45 72 By similarity.
DISULFID 100 122 By similarity.
DISULFID 177 207 By similarity.
DISULFID 234 256 By similarity.
DISULFID 297 309 By similarity.
DISULFID 304 322 By similarity.
DISULFID 316 331 By similarity.
Amino Acid Sequence for NETO2_HUMAN » Neuropilin and tolloid-like protein 2
MALERLCSVL KVLLITVLVV EGIAVAQKTQ DGQNIGIKHI PATQCGIWVR TSNGGHFASP NYPDSYPPNK ECIYILEAAP RQRIELTFDE HYYIEPSFEC RFDHLEVRDG PFGFSPLIDR YCGVKSPPLI RSTGRFMWIK FSSDEELEGL GFRAKYSFIP DPDFTYLGGI LNPIPDCQFE LSGADGIVRS SQVEQEEKTK PGQAVDCIWT IKATPKAKIY LRFLDYQMEH SNECKRNFVA VYDGSSSIEN LKAKFCSTVA NDVMLKTGIG VIRMWADEGS RLSRFRMLFT SFVEPPCTSS TFFCHSNMCI NNSLVCNGVQ NCAYPWDENH CKEKKKAGVF EQITKTHGTI IGITSGIVLV LLIISILVQV KQPRKKVMAC KTAFNKTGFQ EVFDPPHYEL FSLRDKEISA DLADLSEELD NYQKMRRSST ASRCIHDHHC GSQASSVKQS RTNLSSMELP FRNDFAQPQP MKTFNSTFKK SSYTFKQGHE CPEQALEDRV MEEIPCEIYV RGREDSAQAS ISIDF