NETO1_HUMAN » Neuropilin and tolloid-like protein 1

NETO1_HUMAN » Neuropilin and tolloid-like protein 1
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Topology in Plasma membrane
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NETO1_HUMAN » Neuropilin and tolloid-like protein 1 » Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1;
Hydrophobic Thickness 30.8 ± 2.0 Å
Tilt Angle 1 ± 1°
ΔGtransfer -39.7 kcal/mol
ΔGfold -15.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 343-366 (341-367)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 41-152, PDBID: 2QQK, Subunit A, Seq Identity:36%, CUB domain

AA: 172-284, PDBID: 1NT0, Subunit A, Seq Identity:22%, CUB domain

AA: 290-326, PDBID: 3T5O, Subunit A, Seq Identity:43%, Low-density lipoprotein receptor domain class A

UniProt annotation for NETO1_HUMAN » Neuropilin and tolloid-like protein 1
FUNCTION: Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D- aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory (By similarity).

SUBUNIT: Interacts with PLZ domains of DLG2, DLG3 and DLG4 via its C-terminal TRV domain. Interacts with GRIN2A and GRIN2B via its CUB domains (By similarity).

TISSUE SPECIFICITY: Isoform 1 and isoform 2 are retina-specific. Isoform 3 is found in retina as well as at lower levels in adult and fetal brain.

UniProt features for NETO1_HUMAN » Neuropilin and tolloid-like protein 1
SIGNAL 1 22 Potential.
CHAIN 23 533 Neuropilin and tolloid-like protein 1.
DOMAIN 41 155 CUB 1.
DOMAIN 172 287 CUB 2.
DOMAIN 291 327 LDL-receptor class A.
MOTIF 531 533 PDZ-binding.
DISULFID 41 68 By similarity.
DISULFID 96 118 By similarity.
DISULFID 172 202 By similarity.
DISULFID 229 251 By similarity.
DISULFID 292 304 By similarity.
DISULFID 299 317 By similarity.
DISULFID 311 326 By similarity.
Amino Acid Sequence for NETO1_HUMAN » Neuropilin and tolloid-like protein 1
MIHGRSVLHI VASLIILHLS GATKKGTEKQ TTSETQKSVQ CGTWTKHAEG GIFTSPNYPS KYPPDRECIY IIEAAPRQCI ELYFDEKYSI EPSWECKFDH IEVRDGPFGF SPIIGRFCGQ QNPPVIKSSG RFLWIKFFAD GELESMGFSA RYNFTPDPDF KDLGALKPLP ACEFEMGGSE GIVESIQIMK EGKATASEAV DCKWYIRAPP RSKIYLRFLD YEMQNSNECK RNFVAVYDGS SSVEDLKAKF CSTVANDVML RTGLGVIRMW ADEGSRNSRF QMLFTSFQEP PCEGNTFFCH SNMCINNTLV CNGLQNCVYP WDENHCKEKR KTSLLDQLTN TSGTVIGVTS CIVIILIIIS VIVQIKQPRK KYVQRKSDFD QTVFQEVFEP PHYELCTLRG TGATADFADV ADDFENYHKL RRSSSKCIHD HHCGSQLSST KGSRSNLSTR DASILTEMPT QPGKPLIPPM NRRNILVMKH NYSQDAADAC DIDEIEEVPT TSHRLSRHDK AVQRFCLIGS LSKHESEYNT TRV