NEO1_HUMAN » Neogenin

NEO1_HUMAN » Neogenin
Magnify NEO1_HUMAN » NeogeninEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
NEO1_HUMAN » Neogenin » Immunoglobulin superfamily DCC subclass member 2;
Hydrophobic Thickness 37.6 ± 4.4 Å
Tilt Angle 1 ± 1°
ΔGtransfer -31.4 kcal/mol
ΔGfold -25.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 1104-1128 (1102-1138)
Pathways

Cell adhesion molecules (KEGG)

Developmental Biology (Reactome)

PDB 1x5f (429-535), 1x5g (529-631), 1x5h (623-741), 1x5i (719-831), 3p4l (853-1054), 1x5j (853-952), 1x5k (944-1054)
OPM none
Complexes none
Interactions

UNC5B, Complex: NEO1:UNC5B, PubMed

Domains

AA: 55-148, PDBID: 3LAF, Subunit A, Seq Identity:35%, Immunoglobulin domain

AA: 152-225, PDBID: 1CS6, Subunit A, Seq Identity:31%, Immunoglobulin domain

AA: 249-337, PDBID: 3LAF, Subunit A, Seq Identity:44%, Immunoglobulin I-set domain

AA: 341-427, PDBID: 3LAF, Subunit A, Seq Identity:69%, Immunoglobulin I-set domain

AA: 440-525, PDBID: 1X5F, Subunit A, Seq Identity:100%, Fibronectin type III domain

AA: 540-621, PDBID: 1X5G, Subunit A, Seq Identity:100%, Fibronectin type III domain

AA: 635-721, PDBID: 1X5H, Subunit A, Seq Identity:100%, Fibronectin type III domain

AA: 740-820, PDBID: 1X5I, Subunit A, Seq Identity:100%, Fibronectin type III domain

AA: 855-942, PDBID: 1X5J, Subunit A, Seq Identity:100%, Fibronectin type III domain

AA: 956-1044, PDBID: 1X5K, Subunit A, Seq Identity:100%, Fibronectin type III domain

AA: 1158-1461, PDBID: 3AU4, Subunit B, Seq Identity:35%, Neogenin C-terminus

UniProt annotation for NEO1_HUMAN » Neogenin
FUNCTION: Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response.

SUBUNIT: Interacts with MYO10 (By similarity). Interacts with RGMA and RGMB. Interacts with BMP2, BMP4, BMP6, and BMP7.

TISSUE SPECIFICITY: Widely expressed and also in cancer cell lines.

DOMAIN: The Fibronectin repeats 5 and 6 mediate interaction with RGM family molecules.

MISCELLANEOUS: Knockdown of NEO1 in C2C12 cells results in the enhancement of the BMP-2-induced processes of osteoblastic differentiation and phosphorylation of Smad1, Smad5, and Smad8. Conversely, overexpression suppresses these processes.

UniProt features for NEO1_HUMAN » Neogenin
SIGNAL 1 33 Potential.
CHAIN 34 1461 Neogenin.
DOMAIN 52 141 Ig-like C2-type 1.
DOMAIN 152 238 Ig-like C2-type 2.
DOMAIN 243 336 Ig-like C2-type 3.
DOMAIN 341 426 Ig-like C2-type 4.
DOMAIN 439 532 Fibronectin type-III 1.
DOMAIN 539 627 Fibronectin type-III 2.
DOMAIN 633 728 Fibronectin type-III 3.
DOMAIN 735 827 Fibronectin type-III 4.
DOMAIN 853 949 Fibronectin type-III 5.
DOMAIN 954 1051 Fibronectin type-III 6.
DISULFID 74 129 By similarity.
DISULFID 173 221 By similarity.
DISULFID 270 320 By similarity.
DISULFID 362 410 By similarity.
Amino Acid Sequence for NEO1_HUMAN » Neogenin
MAAERGARRL LSTPSFWLYC LLLLGRRAPG AAAARSGSAP QSPGASIRTF TPFYFLVEPV DTLSVRGSSV ILNCSAYSEP SPKIEWKKDG TFLNLVSDDR RQLLPDGSLF ISNVVHSKHN KPDEGYYQCV ATVESLGTII SRTAKLIVAG LPRFTSQPEP SSVYAGNNAI LNCEVNADLV PFVRWEQNRQ PLLLDDRVIK LPSGMLVISN ATEGDGGLYR CVVESGGPPK YSDEVELKVL PDPEVISDLV FLKQPSPLVR VIGQDVVLPC VASGLPTPTI KWMKNEEALD TESSERLVLL AGGSLEISDV TEDDAGTYFC IADNGNETIE AQAELTVQAQ PEFLKQPTNI YAHESMDIVF ECEVTGKPTP TVKWVKNGDM VIPSDYFKIV KEHNLQVLGL VKSDEGFYQC IAENDVGNAQ AGAQLIILEH APATTGPLPS APRDVVASLV STRFIKLTWR TPASDPHGDN LTYSVFYTKE GIARERVENT SHPGEMQVTI QNLMPATVYI FRVMAQNKHG SGESSAPLRV ETQPEVQLPG PAPNLRAYAA SPTSITVTWE TPVSGNGEIQ NYKLYYMEKG TDKEQDVDVS SHSYTINGLK KYTEYSFRVV AYNKHGPGVS TPDVAVRTLS DVPSAAPQNL SLEVRNSKSI MIHWQPPAPA TQNGQITGYK IRYRKASRKS DVTETLVSGT QLSQLIEGLD RGTEYNFRVA ALTINGTGPA TDWLSAETFE SDLDETRVPE VPSSLHVRPL VTSIVVSWTP PENQNIVVRG YAIGYGIGSP HAQTIKVDYK QRYYTIENLD PSSHYVITLK AFNNVGEGIP LYESAVTRPH TDTSEVDLFV INAPYTPVPD PTPMMPPVGV QASILSHDTI RITWADNSLP KHQKITDSRY YTVRWKTNIP ANTKYKNANA TTLSYLVTGL KPNTLYEFSV MVTKGRRSST WSMTAHGTTF ELVPTSPPKD VTVVSKEGKP KTIIVNWQPP SEANGKITGY IIYYSTDVNA EIHDWVIEPV VGNRLTHQIQ ELTLDTPYYF KIQARNSKGM GPMSEAVQFR TPKADSSDKM PNDQASGSGG KGSRLPDLGS DYKPPMSGSN SPHGSPTSPL DSNMLLVIIV SVGVITIVVV VIIAVFCTRR TTSHQKKKRA ACKSVNGSHK YKGNSKDVKP PDLWIHHERL ELKPIDKSPD PNPIMTDTPI PRNSQDITPV DNSMDSNIHQ RRNSYRGHES EDSMSTLAGR RGMRPKMMMP FDSQPPQPVI SAHPIHSLDN PHHHFHSSSL ASPARSHLYH PGSPWPIGTS MSLSDRANST ESVRNTPSTD TMPASSSQTC CTDHQDPEGA TSSSYLASSQ EEDSGQSLPT AHVRPSHPLK SFAVPAIPPP GPPTYDPALP STPLLSQQAL NHHIHSVKTA SIGTLGRSRP PMPVVVPSAP EVQETTRMLE DSESSYEPDE LTKEMAHLEG LMKDLNAITT A