NEM1_YEAST » Nuclear envelope morphology protein 1

NEM1_YEAST » Nuclear envelope morphology protein 1
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Topology in Nuclear outer membrane
Topologyintermembrane space
cytoplasmic side
NEM1_YEAST » Nuclear envelope morphology protein 1 »
Hydrophobic Thickness 34.4 ± 1.6 Å
Tilt Angle 2 ± 1°
ΔGtransfer -22.7 kcal/mol
ΔGfold -7.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 105-127 (105-131)
Pathways none
PDB none
OPM none
Complexes none
Interactions

ANP1, Complex: NEM1:ANP1

BOS1, Complex: BOS1:NEM1

CBP4, Complex: NEM1:CBP4

CUE1, Complex: NEM1:CUE1

GPI8, Complex: NEM1:GPI8

MGA2, Complex: NEM1:MGA2

MPS3, Complex: NEM1:MPS3

SC6B2, Complex: SC6B2:NEM1

SEC12, Complex: NEM1:SEC12

SEC66, Complex: NEM1:SEC66

TLG2, Complex: TLG2:NEM1

Domains

AA: 252-431, PDBID: 2Q5E, Subunit E, Seq Identity:35%, NLI interacting factor-like phosphatase

UniProt annotation for NEM1_YEAST » Nuclear envelope morphology protein 1
FUNCTION: Essential for the formation of a spherical nucleus and meiotic division. Catalytic component of the NEM1-SPO7 complex which acts as a phosphatase and dephosphorylates SMP2.

CATALYTIC ACTIVITY: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.

SUBUNIT: Component of the NEM1-SPO7 complex.

MISCELLANEOUS: Present with 377 molecules/cell in log phase SD medium.

UniProt features for NEM1_YEAST » Nuclear envelope morphology protein 1
CHAIN 1 446 Nuclear envelope morphology protein 1.
DOMAIN 247 424 FCP1 homology.
Amino Acid Sequence for NEM1_YEAST » Nuclear envelope morphology protein 1
MNALKYFSNH LITTKKQKKI NVEVTKNQDL LGPSKEVSNK YTSHSENDCV SEVDQQYDHS SSHLKESDQN QERKNSVPKK PKALRSILIE KIASILWALL LFLPYYLIIK PLMSLWFVFT FPLSVIERRV KHTDKRNRGS NASENELPVS SSNINDSSEK TNPKNCNLNT IPEAVEDDLN ASDEIILQRD NVKGSLLRAQ SVKSRPRSYS KSELSLSNHS SSNTVFGTKR MGRFLFPKKL IPKSVLNTQK KKKLVIDLDE TLIHSASRST THSNSSQGHL VEVKFGLSGI RTLYFIHKRP YCDLFLTKVS KWYDLIIFTA SMKEYADPVI DWLESSFPSS FSKRYYRSDC VLRDGVGYIK DLSIVKDSEE NGKGSSSSLD DVIIIDNSPV SYAMNVDNAI QVEGWISDPT DTDLLNLLPF LEAMRYSTDV RNILALKHGE KAFNIN