NDUC2_HUMAN » NADH dehydrogenase [ubiquinone] 1 subunit C2

NDUC2_HUMAN » NADH dehydrogenase [ubiquinone] 1 subunit C2
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Topology in Mitochondrial inner membrane
Topologyintermembrane space
mitochondrial matrix side
NDUC2_HUMAN » NADH dehydrogenase [ubiquinone] 1 subunit C2 » Complex I-B14.5b;CI-B14.5b; Human lung cancer oncogene 1 protein;HLC-1; NADH-ubiquinone oxidoreductase subunit B14.5b;
Hydrophobic Thickness 26.8 ± 2.5 Å
Tilt Angle 9 ± 16°
ΔGtransfer -18.0 kcal/mol
ΔGfold -5.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Und
TM Segments 56-74 (51-78)
Pathways

Alzheimer's disease (KEGG)

Huntington's disease (KEGG)

Oxidative phosphorylation (KEGG)

Parkinson's disease (KEGG)

PDB none
OPM none
Complexes none
Interactions

COA3, Complex: NDUC2:COA3

Domains

AA: 7-119, NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2)

UniProt annotation for NDUC2_HUMAN » NADH dehydrogenase [ubiquinone] 1 subunit C2
FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

SUBUNIT: Complex I is composed of 45 different subunits.

UniProt features for NDUC2_HUMAN » NADH dehydrogenase [ubiquinone] 1 subunit C2
CHAIN 1 119 NADH dehydrogenase [ubiquinone] 1 subunit C2.
Amino Acid Sequence for NDUC2_HUMAN » NADH dehydrogenase [ubiquinone] 1 subunit C2
MIARRNPEPL RFLPDEARSL PPPKLTDPRL LYIGFLGYCS GLIDNLIRRR PIATAGLHRQ LLYITAFFFA GYYLVKREDY LYAVRDREMF GYMKLHPEDF PEEDKKTYGE IFEKFHPIR