NCTR3_HUMAN » Natural cytotoxicity triggering receptor 3

NCTR3_HUMAN » Natural cytotoxicity triggering receptor 3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
NCTR3_HUMAN » Natural cytotoxicity triggering receptor 3 » Activating natural killer receptor p30;Natural killer cell p30-related protein;NK-p30; NKp30;
Hydrophobic Thickness 30.4 ± 3.0 Å
Tilt Angle 0 ± 0°
ΔGtransfer -32.6 kcal/mol
ΔGfold -7.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 139-161 (136-165)
Pathways

Natural killer cell mediated cytotoxicity (KEGG)

PDB 3noi (A/B=18-130), 3pv6 (B=19-135)
OPM none
Complexes

NCTR3:NR3L1_HUMAN

NCTR3:NCTR3_HUMAN

Interactions

CD3Z, Complex: CD3Z:NCTR3, PubMed

NCTR3, Complex: Homodimer of natural cytotoxicity triggering receptor 3, PDBID: 3NOI

NR3L1, Complex: NCTR3:NR3L1, PDBID: 3PV6

Domains

AA: 22-128, PDBID: 3NOI, Subunit A, Seq Identity:100%, Immunoglobulin V-set domain

UniProt annotation for NCTR3_HUMAN » Natural cytotoxicity triggering receptor 3
FUNCTION: Cytotoxicity-activating receptor that contributes to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation.

SUBUNIT: Homodimer in the unliganted form. Interacts with CD3Z. Interacts with and is activated by binding to NCR3LG1. Interacts with and is activated by binding to BAG6.

TISSUE SPECIFICITY: Selectively expressed by all resting and activated NK cells and weakly expressed in spleen.

UniProt features for NCTR3_HUMAN » Natural cytotoxicity triggering receptor 3
SIGNAL 1 18 Potential.
CHAIN 19 201 Natural cytotoxicity triggering receptor 3.
DOMAIN 19 126 Ig-like.
DISULFID 39 108
Amino Acid Sequence for NCTR3_HUMAN » Natural cytotoxicity triggering receptor 3
MAWMLLLILI MVHPGSCALW VSQPPEIRTL EGSSAFLPCS FNASQGRLAI GSVTWFRDEV VPGKEVRNGT PEFRGRLAPL ASSRFLHDHQ AELHIRDVRG HDASIYVCRV EVLGLGVGTG NGTRLVVEKE HPQLGAGTVL LLRAGFYAVS FLSVAVGSTV YYQGKCLTWK GPRRQLPAVV PAPLPPPCGS SAHLLPPVPG G