NCTR2_HUMAN » Natural cytotoxicity triggering receptor 2

NCTR2_HUMAN » Natural cytotoxicity triggering receptor 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
NCTR2_HUMAN » Natural cytotoxicity triggering receptor 2 » Lymphocyte antigen 95 homolog;NK cell-activating receptor;Natural killer cell p44-related protein;NK-p44; NKp44;
Hydrophobic Thickness 35.2 ± 3.0 Å
Tilt Angle 50 ± 0°
ΔGtransfer -26.4 kcal/mol
ΔGfold -9.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 188-220 (188-224)
Pathways

Immune System (Reactome)

Natural killer cell mediated cytotoxicity (KEGG)

PDB 1hkf (A=19-130)
OPM none
Complexes none
Interactions

TYOBP, Complex: TYOBP:NCTR2, PubMed

Domains

AA: 22-129, PDBID: 1HKF, Subunit A, Seq Identity:100%, Immunoglobulin V-set domain

UniProt annotation for NCTR2_HUMAN » Natural cytotoxicity triggering receptor 2
FUNCTION: Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

SUBUNIT: Interacts with TYROBP/DAP12. Interacts with KMT2E isoform NKp44L.

TISSUE SPECIFICITY: Selectively expressed by activated NK cells and by in vitro cultured (i.e. activated) TCRg/d lymphoid cells.

UniProt features for NCTR2_HUMAN » Natural cytotoxicity triggering receptor 2
SIGNAL 1 21 Potential.
CHAIN 22 276 Natural cytotoxicity triggering receptor 2.
DOMAIN 22 120 Ig-like.
DISULFID 40 109 Potential.
DISULFID 55 63 Potential.
Amino Acid Sequence for NCTR2_HUMAN » Natural cytotoxicity triggering receptor 2
MAWRALHPLL LLLLLFPGSQ AQSKAQVLQS VAGQTLTVRC QYPPTGSLYE KKGWCKEASA LVCIRLVTSS KPRTMAWTSR FTIWDDPDAG FFTVTMTDLR EEDSGHYWCR IYRPSDNSVS KSVRFYLVVS PASASTQTSW TPRDLVSSQT QTQSCVPPTA GARQAPESPS TIPVPSQPQN STLRPGPAAP IALVPVFCGL LVAKSLVLSA LLVWWGDIWW KTMMELRSLD TQKATCHLQQ VTDLPWTSVS SPVEREILYH TVARTKISDD DDEHTL