NCTR1_HUMAN » Natural cytotoxicity triggering receptor 1

NCTR1_HUMAN » Natural cytotoxicity triggering receptor 1
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Topology in Vacuolar membrane
Topologyvacuole lumenal side
cytoplasmic side
NCTR1_HUMAN » Natural cytotoxicity triggering receptor 1 » Lymphocyte antigen 94 homolog;NK cell-activating receptor;Natural killer cell p46-related protein;NK-p46; NKp46; hNKp46;
Hydrophobic Thickness 31.2 ± 3.6 Å
Tilt Angle 22 ± 6°
ΔGtransfer -26.7 kcal/mol
ΔGfold -18.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 256-278 (250-285)
Pathways

Natural killer cell mediated cytotoxicity (KEGG)

PDB 1p6f (22-263), 1oll (25-212)
OPM none
Complexes none
Interactions

CD3Z, Complex: NCTR1:CD3Z, PubMed

FCERG, Complex: FCERG:NCTR1, PubMed

Domains

AA: 28-117, PDBID: 1oll, Subunit A, Seq Identity:100%, Immunoglobulin domain

AA: 123-195, PDBID: 1oll, Subunit A, Seq Identity:100%, Immunoglobulin domain

UniProt annotation for NCTR1_HUMAN » Natural cytotoxicity triggering receptor 1
FUNCTION: Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

SUBUNIT: Interacts with CD247 and FCER1G.

TISSUE SPECIFICITY: Selectively expressed by both resting and activated NK cells.

UniProt features for NCTR1_HUMAN » Natural cytotoxicity triggering receptor 1
SIGNAL 1 21 Potential.
CHAIN 22 304 Natural cytotoxicity triggering receptor 1.
DOMAIN 34 118 Ig-like 1.
DOMAIN 129 211 Ig-like 2.
DISULFID 49 98
DISULFID 144 190
Amino Acid Sequence for NCTR1_HUMAN » Natural cytotoxicity triggering receptor 1
MSSTLPALLC VGLCLSQRIS AQQQTLPKPF IWAEPHFMVP KEKQVTICCQ GNYGAVEYQL HFEGSLFAVD RPKPPERINK VKFYIPDMNS RMAGQYSCIY RVGELWSEPS NLLDLVVTEM YDTPTLSVHP GPEVISGEKV TFYCRLDTAT SMFLLLKEGR SSHVQRGYGK VQAEFPLGPV TTAHRGTYRC FGSYNNHAWS FPSEPVKLLV TGDIENTSLA PEDPTFPADT WGTYLLTTET GLQKDHALWD HTAQNLLRMG LAFLVLVALV WFLVEDWLSR KRTRERASRA STWEGRRRLN TQTL