NCAM2_HUMAN » Neural cell adhesion molecule 2

NCAM2_HUMAN » Neural cell adhesion molecule 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
NCAM2_HUMAN » Neural cell adhesion molecule 2 » N-CAM-2; NCAM-2;
Hydrophobic Thickness 35.6 ± 3.4 Å
Tilt Angle 31 ± 3°
ΔGtransfer -26.1 kcal/mol
ΔGfold -16.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 694-722 (694-722)
Pathways

Cell adhesion molecules (KEGG)

Prion diseases (KEGG)

PDB 2v5t (115-301), 2xy2 (19-207), 2wim (19-301), 2xy1 (209-398), 2xyc (301-591), 2jll (301-689), 2doc (486-591), 2kbg (592-693), 2vaj (A=21-113)
OPM none
Complexes none
Interactions

APRIO, Complex: APRIO.PRIO:NCAM2, PubMed

ESR1, Complex: ESR1:NCAM2, PubMed

Domains

AA: 21-111, PDBID: 2VAJ, Subunit A, Seq Identity:100%, Immunoglobulin I-set domain

AA: 115-198, PDBID: 2V5T, Subunit A, Seq Identity:100%, Immunoglobulin I-set domain

AA: 211-298, PDBID: 2V5T, Subunit A, Seq Identity:100%, Immunoglobulin I-set domain

AA: 302-397, PDBID: 2JLL, Subunit A, Seq Identity:100%, Immunoglobulin I-set domain

AA: 400-479, PDBID: 2JLL, Subunit A, Seq Identity:100%, Immunoglobulin domain

AA: 497-581, PDBID: 2DOC, Subunit A, Seq Identity:100%, Fibronectin type III domain

AA: 593-678, PDBID: 2JLL, Subunit A, Seq Identity:100%, Fibronectin type III domain

UniProt annotation for NCAM2_HUMAN » Neural cell adhesion molecule 2
FUNCTION: May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons.

TISSUE SPECIFICITY: Expressed most strongly in adult and fetal brain.

UniProt features for NCAM2_HUMAN » Neural cell adhesion molecule 2
SIGNAL 1 19 Potential.
CHAIN 20 837 Neural cell adhesion molecule 2.
DOMAIN 21 108 Ig-like C2-type 1.
DOMAIN 113 202 Ig-like C2-type 2.
DOMAIN 208 297 Ig-like C2-type 3.
DOMAIN 302 396 Ig-like C2-type 4.
DOMAIN 401 491 Ig-like C2-type 5.
DOMAIN 496 588 Fibronectin type-III 1.
DOMAIN 590 684 Fibronectin type-III 2.
DISULFID 42 93 Probable.
DISULFID 136 186 Probable.
DISULFID 232 281 Probable.
DISULFID 322 380 Probable.
DISULFID 422 475 Probable.
Amino Acid Sequence for NCAM2_HUMAN » Neural cell adhesion molecule 2
MSLLLSFYLL GLLVSSGQAL LQVTISLSKV ELSVGESKFF TCTAIGEPES IDWYNPQGEK IISTQRVVVQ KEGVRSRLTI YNANIEDAGI YRCQATDAKG QTQEATVVLE IYQKLTFREV VSPQEFKQGE DAEVVCRVSS SPAPAVSWLY HNEEVTTISD NRFAMLANNN LQILNINKSD EGIYRCEGRV EARGEIDFRD IIVIVNVPPA ISMPQKSFNA TAERGEEMTF SCRASGSPEP AISWFRNGKL IEENEKYILK GSNTELTVRN IINSDGGPYV CRATNKAGED EKQAFLQVFV QPHIIQLKNE TTYENGQVTL VCDAEGEPIP EITWKRAVDG FTFTEGDKSL DGRIEVKGQH GSSSLHIKDV KLSDSGRYDC EAASRIGGHQ KSMYLDIEYA PKFISNQTIY YSWEGNPINI SCDVKSNPPA SIHWRRDKLV LPAKNTTNLK TYSTGRKMIL EIAPTSDNDF GRYNCTATNH IGTRFQEYIL ALADVPSSPY GVKIIELSQT TAKVSFNKPD SHGGVPIHHY QVDVKEVASE IWKIVRSHGV QTMVVLNNLE PNTTYEIRVA AVNGKGQGDY SKIEIFQTLP VREPSPPSIH GQPSSGKSFK LSITKQDDGG APILEYIVKY RSKDKEDQWL EKKVQGNKDH IILEHLQWTM GYEVQITAAN RLGYSEPTVY EFSMPPKPNI IKDTLFNGLG LGAVIGLGVA ALLLILVVTD VSCFFIRQCG LLMCITRRMC GKKSGSSGKS KELEEGKAAY LKDGSKEPIV EMRTEDERVT NHEDGSPVNE PNETTPLTEP EKLPLKEEDG KEALNPETIE IKVSNDIIQS KEDDSKA