NCAM1_HUMAN » Neural cell adhesion molecule 1

NCAM1_HUMAN » Neural cell adhesion molecule 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
NCAM1_HUMAN » Neural cell adhesion molecule 1 » N-CAM-1; NCAM-1;
Hydrophobic Thickness 36.8 ± 2.6 Å
Tilt Angle 0 ± 0°
ΔGtransfer -46.5 kcal/mol
ΔGfold -21.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 721-746 (721-748)
Pathways

Cell adhesion molecules (KEGG)

Developmental Biology (Reactome)

Immune System (Reactome)

Prion diseases (KEGG)

PDB 2haz (508-608), 2e3v (510-619), 2vkx (A/B...=506-702), 3mtr (A/B=414-611), 2vkw (A/B=506-702)
OPM none
Complexes

NCAM1:NCAM1_HUMAN

Interactions

APRIO, Complex: NCAM1:APRIO.PRIO, PubMed

EGFR, Complex: EGFR:NCAM1, PubMed

FGFR1, Complex: FGFR1:NCAM1, PubMed

L1CAM, Complex: NCAM1:L1CAM, PubMed

NCAM1, Complex: Homodimer of neural cell adhesion molecule 1, PDBID: 2VKW

SIA8B, Complex: NCAM1:SIA8B, PubMed

SIA8C, Complex: SIA8C:NCAM1, PubMed

SIA8D, Complex: NCAM1:SIA8D, PubMed

Domains

AA: 20-114, PDBID: 1EPF, Subunit B, Seq Identity:94%, Immunoglobulin I-set domain

AA: 119-192, PDBID: 1EPF, Subunit D, Seq Identity:98%, Immunoglobulin domain

AA: 214-304, PDBID: 1QZ1, Subunit A, Seq Identity:81%, Immunoglobulin I-set domain

AA: 307-399, PDBID: 2YD2, Subunit A, Seq Identity:27%, Immunoglobulin domain

AA: 418-505, PDBID: 3MTR, Subunit A, Seq Identity:100%, Immunoglobulin I-set domain

AA: 508-598, PDBID: 2E3V, Subunit C, Seq Identity:100%, Fibronectin type III domain

AA: 610-696, PDBID: 2VKW, Subunit A, Seq Identity:100%, Fibronectin type III domain

UniProt annotation for NCAM1_HUMAN » Neural cell adhesion molecule 1
FUNCTION: This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
UniProt features for NCAM1_HUMAN » Neural cell adhesion molecule 1
SIGNAL 1 19 By similarity.
CHAIN 20 858 Neural cell adhesion molecule 1.
DOMAIN 20 111 Ig-like C2-type 1.
DOMAIN 116 205 Ig-like C2-type 2.
DOMAIN 212 301 Ig-like C2-type 3.
DOMAIN 308 413 Ig-like C2-type 4.
DOMAIN 416 501 Ig-like C2-type 5.
DOMAIN 506 605 Fibronectin type-III 1.
DOMAIN 608 702 Fibronectin type-III 2.
DISULFID 41 96 Probable.
DISULFID 139 189 Probable.
DISULFID 235 287 Probable.
DISULFID 329 395 Probable.
DISULFID 436 489 Probable.
Amino Acid Sequence for NCAM1_HUMAN » Neural cell adhesion molecule 1
MLQTKDLIWT LFFLGTAVSL QVDIVPSQGE ISVGESKFFL CQVAGDAKDK DISWFSPNGE KLTPNQQRIS VVWNDDSSST LTIYNANIDD AGIYKCVVTG EDGSESEATV NVKIFQKLMF KNAPTPQEFR EGEDAVIVCD VVSSLPPTII WKHKGRDVIL KKDVRFIVLS NNYLQIRGIK KTDEGTYRCE GRILARGEIN FKDIQVIVNV PPTIQARQNI VNATANLGQS VTLVCDAEGF PEPTMSWTKD GEQIEQEEDD EKYIFSDDSS QLTIKKVDKN DEAEYICIAE NKAGEQDATI HLKVFAKPKI TYVENQTAME LEEQVTLTCE ASGDPIPSIT WRTSTRNISS EEKASWTRPE KQETLDGHMV VRSHARVSSL TLKSIQYTDA GEYICTASNT IGQDSQSMYL EVQYAPKLQG PVAVYTWEGN QVNITCEVFA YPSATISWFR DGQLLPSSNY SNIKIYNTPS ASYLEVTPDS ENDFGNYNCT AVNRIGQESL EFILVQADTP SSPSIDQVEP YSSTAQVQFD EPEATGGVPI LKYKAEWRAV GEEVWHSKWY DAKEASMEGI VTIVGLKPET TYAVRLAALN GKGLGEISAA SEFKTQPVQG EPSAPKLEGQ MGEDGNSIKV NLIKQDDGGS PIRHYLVRYR ALSSEWKPEI RLPSGSDHVM LKSLDWNAEY EVYVVAENQQ GKSKAAHFVF RTSAQPTAIP ANGSPTSGLS TGAIVGILIV IFVLLLVVVD ITCYFLNKCG LFMCIAVNLC GKAGPGAKGK DMEEGKAAFS KDESKEPIVE VRTEEERTPN HDGGKHTEPN ETTPLTEPEK GPVEAKPECQ ETETKPAPAE VKTVPNDATQ TKENESKA