NB5R1_HUMAN » NADH-cytochrome b5 reductase 1

NB5R1_HUMAN » NADH-cytochrome b5 reductase 1
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
NB5R1_HUMAN » NADH-cytochrome b5 reductase 1 » b5R.1; Humb5R2;NAD(P)H:quinone oxidoreductase type 3 polypeptide A2;
Hydrophobic Thickness 31.2 ± 3.2 Å
Tilt Angle 31 ± 0°
ΔGtransfer -18.5 kcal/mol
ΔGfold -13.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 7-30 (7-34)
Pathways

Amino sugar and nucleotide sugar metabolism (KEGG)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 48-155, PDBID: 1NDH, Subunit A, Seq Identity:72%, Oxidoreductase FAD-binding domain

AA: 181-289, PDBID: 1NDH, Subunit A, Seq Identity:66%, Oxidoreductase NAD-binding domain

UniProt annotation for NB5R1_HUMAN » NADH-cytochrome b5 reductase 1
FUNCTION: NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.

CATALYTIC ACTIVITY: NADH + 2 ferricytochrome b5 = NAD(+) + H(+) + 2 ferrocytochrome b5.

TISSUE SPECIFICITY: Widely expressed.

UniProt features for NB5R1_HUMAN » NADH-cytochrome b5 reductase 1
CHAIN 1 305 NADH-cytochrome b5 reductase 1.
DOMAIN 44 156 FAD-binding FR-type.
Amino Acid Sequence for NB5R1_HUMAN » NADH-cytochrome b5 reductase 1
MGIQTSPVLL ASLGVGLVTL LGLAVGSYLV RRSRRPQVTL LDPNEKYLLR LLDKTTVSHN TKRFRFALPT AHHTLGLPVG KHIYLSTRID GSLVIRPYTP VTSDEDQGYV DLVIKVYLKG VHPKFPEGGK MSQYLDSLKV GDVVEFRGPS GLLTYTGKGH FNIQPNKKSP PEPRVAKKLG MIAGGTGITP MLQLIRAILK VPEDPTQCFL LFANQTEKDI ILREDLEELQ ARYPNRFKLW FTLDHPPKDW AYSKGFVTAD MIREHLPAPG DDVLVLLCGP PPMVQLACHP NLDKLGYSQK MRFTY