|N2DL4_HUMAN » NKG2D ligand 4 » N2DL-4; NKG2DL4; Lymphocyte effector toxicity activation ligand;RAE-1-like transcript 4;RL-4; Retinoic acid early transcript 1E;|
|Hydrophobic Thickness||35.6 ± 2.2 Å|
|Tilt Angle||22 ± 4°|
|Links||UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC|
|TM Segments||224-248 (224-251)|
Immune System (Reactome)
AA: 29-202, PDBID: 1KCG, Subunit C, Seq Identity:42%, Class I Histocompatibility antigen, domains alpha 1 and 2
|UniProt annotation for N2DL4_HUMAN » NKG2D ligand 4|
|FUNCTION: Ligand for the KLRK1 receptor. Delivers activating signals to NK cells and promotes tumor immune surveillance by inducing the expansion of anti-tumor cytotoxic lymphocytes. SUBUNIT: Binds to KLRK1/NKG2D. Does not interacts with the CMV glycoprotein UL16. TISSUE SPECIFICITY: Predominantly expressed in the skin, but also expressed in testis and trachea. Up-regulated in tumor cells of different origins. Expression progressively decreased after treatment of tumor cells with retinoic acid. MISCELLANEOUS: The ULBPs are unusual members of the extended MHC class I superfamily, because they do not contain the alpha 3 domain and they lack a transmembrane domain. They are unlikely to present peptides.|
|UniProt features for N2DL4_HUMAN » NKG2D ligand 4|
SIGNAL 1 30 Potential. |
CHAIN 31 263 NKG2D ligand 4.
REGION 31 116 MHC class I alpha-1 like.
REGION 117 207 MHC class I alpha-2 like.
DISULFID 126 189 By similarity.
|Amino Acid Sequence for N2DL4_HUMAN » NKG2D ligand 4|
|MRRISLTSSP VRLLLFLLLL LIALEIMVGG HSLCFNFTIK SLSRPGQPWC EAQVFLNKNL FLQYNSDNNM VKPLGLLGKK VYATSTWGEL TQTLGEVGRD LRMLLCDIKP QIKTSDPSTL QVEMFCQREA ERCTGASWQF ATNGEKSLLF DAMNMTWTVI NHEASKIKET WKKDRGLEKY FRKLSKGDCD HWLREFLGHW EAMPEPTVSP VNASDIHWSS SSLPDRWIIL GAFILLVLMG IVLICVWWQN GEWQAGLWPL RTS|